Fomivirsen

Names

[ Name ]:
Fomivirsen

[Synonym ]:
Isis 2922

Biological Activity

[Description]:

Fomivirsen (ISIS-2922 free base) is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen is an antiviral agent that is used cytomegalovirus retinitis (CMV) research, incluiding in AIDs. Fomivirsen binds to and degrades the mRNAs encoding CMV immediate-early 2 protein, thus inhibiting virus proliferation[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> CMV

[References]

[1]. M D de Smet, et al. Fomivirsen- a phosphorothioate oligonucleotide for the treatment of CMV retinitis. Ocul Immunol Inflamm. 1999 Dec;7(3-4):189-98.

[2]. Anna Kilanowska, et al. In vivo and in vitro studies of antisense oligonucleotides – a review. (Review Article) RSC Adv., 2020, 10, 34501-34516.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀₄H₂₆₃N₆₃O₁₁₄P₂₀S₂₀

[ Molecular Weight ]:
6682.40000

[ Exact Mass ]:
6677.59000

[ PSA ]:
3279.10000

[ LogP ]:
15.76190

Related Compounds

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