CaSR antagonist-1

Modify Date: 2024-03-14 12:51:47

CaSR antagonist-1 Structure
CaSR antagonist-1 structure
Common Name CaSR antagonist-1
CAS Number 1219811-83-2 Molecular Weight 497.58
Density N/A Boiling Point N/A
Molecular Formula C29H24FN3O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CaSR antagonist-1


CaSRantagonist-1 is a calcium sensing receptor (CaSR) antagonistwith an IC50 value of 50 nM. CaSRantagonist-1 can be used for the research of disorders associated with abnormalbone or mineral homeostasis such as osteoporosis[1].

 Names

Name CaSR antagonist-1

 CaSR antagonist-1 Biological Activity

Description CaSRantagonist-1 is a calcium sensing receptor (CaSR) antagonistwith an IC50 value of 50 nM. CaSRantagonist-1 can be used for the research of disorders associated with abnormalbone or mineral homeostasis such as osteoporosis[1].
Related Catalog
Target

IC50:50 nM (CaSR)[1].EC50:>50 μM (hPXR Gene reporter assay)[1].

References

[1]. Ramanjulu JM, et al. Overcoming the Pregnane XReceptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction.ACS Med Chem Lett. 2021 Aug 10;12(9):1396-1404.  

 Chemical & Physical Properties

Molecular Formula C29H24FN3O2S
Molecular Weight 497.58
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