CaSR antagonist-1

Names

[ CAS No. ]:
1219811-83-2

[ Name ]:
CaSR antagonist-1

Biological Activity

[Description]:

CaSRantagonist-1 is a calcium sensing receptor (CaSR) antagonistwith an IC50 value of 50 nM. CaSRantagonist-1 can be used for the research of disorders associated with abnormalbone or mineral homeostasis such as osteoporosis[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> CaSR

[Target]

IC50:50 nM (CaSR)[1].EC50:＞50 μM (hPXR Gene reporter assay)[1].

[References]

[1]. Ramanjulu JM, et al. Overcoming the Pregnane XReceptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction.ACS Med Chem Lett. 2021 Aug 10;12(9):1396-1404.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₂₄FN₃O₂S

[ Molecular Weight ]:
497.58

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.