11-Azidoundecanoic acid

Modify Date: 2024-01-06 18:06:06

11-Azidoundecanoic acid Structure
11-Azidoundecanoic acid structure
Common Name 11-Azidoundecanoic acid
CAS Number 118162-45-1 Molecular Weight 227.30300
Density N/A Boiling Point N/A
Molecular Formula C11H21N3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 11-Azidoundecanoic acid


11-Azidoundecanoic acid is a click chemistry reagent containing an azide group. 11-Azidoundecanoic acid acts as a hydrophobic bioconjugation linker that can be further modified at the azido-position using Staudinger ligation or Click-chemistry. 11-Azidoundecanoic acid is substrate of lipoic acid ligase (LpIA) for labeling[1][2].

 Names

Name ω-azido undecanoic acid
Synonym More Synonyms

 11-Azidoundecanoic acid Biological Activity

Description 11-Azidoundecanoic acid is a click chemistry reagent containing an azide group. 11-Azidoundecanoic acid acts as a hydrophobic bioconjugation linker that can be further modified at the azido-position using Staudinger ligation or Click-chemistry. 11-Azidoundecanoic acid is substrate of lipoic acid ligase (LpIA) for labeling[1][2].
Related Catalog
In Vitro The microbial lipoic acid ligase (LplA) can specifically attach an alkyl azide onto an engineered LplA acceptor peptide (LAP). Then the alkyl azide selectively derivatizes with cyclooctyne conjugates to various probes[1]. LplA method should provide general access to biochemical and imaging studies of cell surface proteins, using small fluorophores introduced via a short peptide tag[1].
References

[1]. Fernández-Suárez M, et al. Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes. Nat Biotechnol. 2007 Dec;25(12):1483-7.

[2]. Heal WP, et al. N-Myristoyl transferase-mediated protein labelling in vivo. Org Biomol Chem. 2008 Jul 7;6(13):2308-15.

 Chemical & Physical Properties

Molecular Formula C11H21N3O2
Molecular Weight 227.30300
Exact Mass 227.16300
PSA 87.05000
LogP 3.34496

 Synonyms

.11-azidoundecanoicacid
.11-azidononanoic acid
.11-azidoundecanoic acid
.11-azideundecanoic acid
ADA
.11-AZIDOUNDECANOIC ACID