BOT-64

Modify Date: 2024-01-03 17:43:28

BOT-64 structure	Common Name	BOT-64
	CAS Number	113760-29-5	Molecular Weight	273.35
	Density	1.27±0.1 g/cm3	Boiling Point	402.1±48.0 °C
	Molecular Formula	C₁₅H₁₅NO₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BOT-64

BOT-64 is an inhibitory κB (IκB) kinase β (IKKβ) inhibitor with an IC50 of 1 µM. BOT-64 blocks lipopolysaccharide-induced nuclear factor-κB activation and nuclear factor-κB-regulated inflammatory gene transcription[1].

Name	6,6-dimethyl-2-phenylimino-5,7-dihydro-1,3-benzoxathiol-4-one
Synonym	More Synonyms

Description	BOT-64 is an inhibitory κB (IκB) kinase β (IKKβ) inhibitor with an IC50 of 1 µM. BOT-64 blocks lipopolysaccharide-induced nuclear factor-κB activation and nuclear factor-κB-regulated inflammatory gene transcription[1].
Related Catalog	Signaling Pathways >> NF-κB >> IKK Research Areas >> Inflammation/Immunology
Target	IKKβ:1 μM (IC50)
In Vivo	BOT-64 (3-30 mg/kg) increases the survival rates of endotoxin LPS-shocked mice[1].
References	[1]. Kim BH, et al. Benzoxathiole derivative blocks lipopolysaccharide-induced nuclear factor-kappaB activation and nuclear factor-kappaB-regulated gene transcription through inactivating inhibitory kappaB kinase beta. Mol Pharmacol. 2008 Apr;73(4):1309-18.

Density	1.27±0.1 g/cm3
Boiling Point	402.1±48.0 °C
Molecular Formula	C₁₅H₁₅NO₂S
Molecular Weight	273.35
Exact Mass	273.08200
PSA	70.81000
LogP	3.72860
Storage condition	20°C

6,6-dimethyl-2-(phenylimino)-6,7-dihydro-5H-benzo[1,3]oxathiol-4-one

1,3-Benzoxathiol-4(5H)-one,6,7-dihydro-6,6-dimethyl-2-(phenylimino)

2-phenylimino-4-oxo-4,5,6,7-tetrahydro-6,6-dimethyl-1,3-benzoxathiole

6,6-dimethyl-2-(phenylimino)-6,7-dihydrobenzo[d][1,3]oxathiol-4(5H)-one

BOT-64

Use of BOT-64

Names

BOT-64 Biological Activity

Chemical & Physical Properties

Synonyms