113760-29-5

113760-29-5 structure

Name: BOT-64
Chemical Name: 6,6-dimethyl-2-phenylimino-5,7-dihydro-1,3-benzoxathiol-4-one
CAS Number: 113760-29-5
Molecular Formula: C₁₅H₁₅NO₂S
Molecular Weight: 273.35
Catalog: Signaling Pathways NF-κB IKK
Create Date: 2017-08-26 02:46:22
Modify Date: 2024-01-03 17:43:28
BOT-64 is an inhibitory κB (IκB) kinase β (IKKβ) inhibitor with an IC50 of 1 µM. BOT-64 blocks lipopolysaccharide-induced nuclear factor-κB activation and nuclear factor-κB-regulated inflammatory gene transcription[1].

Name	6,6-dimethyl-2-phenylimino-5,7-dihydro-1,3-benzoxathiol-4-one
Synonyms	6,6-dimethyl-2-(phenylimino)-6,7-dihydro-5H-benzo[1,3]oxathiol-4-one 1,3-Benzoxathiol-4(5H)-one,6,7-dihydro-6,6-dimethyl-2-(phenylimino) 2-phenylimino-4-oxo-4,5,6,7-tetrahydro-6,6-dimethyl-1,3-benzoxathiole 6,6-dimethyl-2-(phenylimino)-6,7-dihydrobenzo[d][1,3]oxathiol-4(5H)-one

Description	BOT-64 is an inhibitory κB (IκB) kinase β (IKKβ) inhibitor with an IC50 of 1 µM. BOT-64 blocks lipopolysaccharide-induced nuclear factor-κB activation and nuclear factor-κB-regulated inflammatory gene transcription[1].
Related Catalog	Signaling Pathways >> NF-κB >> IKK Research Areas >> Inflammation/Immunology
Target	IKKβ:1 μM (IC50)
In Vivo	BOT-64 (3-30 mg/kg) increases the survival rates of endotoxin LPS-shocked mice[1].
References	[1]. Kim BH, et al. Benzoxathiole derivative blocks lipopolysaccharide-induced nuclear factor-kappaB activation and nuclear factor-kappaB-regulated gene transcription through inactivating inhibitory kappaB kinase beta. Mol Pharmacol. 2008 Apr;73(4):1309-18.