Dendrotoxin-I

Modify Date: 2024-01-24 17:26:34

Dendrotoxin-I structure	Common Name	Dendrotoxin-I
	CAS Number	107950-33-4	Molecular Weight	N/A
	Density	N/A	Boiling Point	N/A
	Molecular Formula	N/A	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Dendrotoxin-I

Dendrotoxin-I is a potent K+ channels blocker and targets voltage-gated potassium channel subunits KV1.1 and KV1.2. Dendrotoxin-I is a neurotoxin isolated from thevenom of Dendroaspis snakes[1][2][3].

Name	DENDROTOXIN I

Description	Dendrotoxin-I is a potent K+ channels blocker and targets voltage-gated potassium channel subunits KV1.1 and KV1.2. Dendrotoxin-I is a neurotoxin isolated from thevenom of Dendroaspis snakes[1][2][3].
Related Catalog	Research Areas >> Cancer Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
In Vivo	Dendrotoxin-I (5 mg/kg; IV) displays a significant tumor growth inhibition effect combined with hyperthermia[3]. Animal Model: Nude mice with MCF-7 cells[3] Dosage: 5 mg/kg Administration: IV Result: Displayed a significanttumor growth inhibition effect combined with hyperthermia. Could not keep on inhibiting the growth of tumor at the later period of treatment.
References	[1]. H Rehm, et al. Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4919-23. [2]. Tess Wright, et al. Firing frequency and entrainment maintained in primary auditory neurons in the presence of combined BDNF and NT3. Sci Rep. 2016 Jun 23;6:28584. [3]. Hui Zhang, et al. Preparation, characterization, and pharmacodynamics of thermosensitive liposomes containing docetaxel. J Pharm Sci. 2014 Jul;103(7):2177-2183.

Appearance of Characters	lyophilized powder
Storage condition	−20°C

WGK Germany	3