MCH-1 antagonist 1
Modify Date: 2024-01-02 11:14:19
MCH-1 antagonist 1 structure
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Common Name | MCH-1 antagonist 1 | ||
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| CAS Number | 1039825-68-7 | Molecular Weight | 414.50000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H26N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MCH-1 antagonist 1MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC50 of 10 μM. |
| Name | 4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one |
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| Synonym | More Synonyms |
| Description | MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC50 of 10 μM. |
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| Related Catalog | |
| Target |
MCH-1:2.6 nM (Ki) CYP3A4:10 μM (IC50) |
| In Vitro | MCH-1 antagonist 1 (Compound 1) also inhibits cytochrome P450 3A4 (CYP3A4) with an IC50 of 10 μM[1]. |
| In Vivo | MCH-1 antagonist 1 is administered to male C57BL/6J DIO mice to assess their pharmacokinetic profile. Effect of MCH-1 antagonist 1 (dosed at 30 mg/kg, po) is measured on the body weight of DIO mice with the AUC0-6 h of 14760 h*ng/mL[1]. |
| References |
| Molecular Formula | C25H26N4O2 |
|---|---|
| Molecular Weight | 414.50000 |
| Exact Mass | 414.20600 |
| PSA | 52.29000 |
| LogP | 3.79990 |
| Storage condition | 2-8℃ |
| MCH-1 antagonist 1 |