A-933548

Modify Date: 2024-04-08 18:00:10

A-933548 Structure
A-933548 structure
Common Name A-933548
CAS Number 1037826-43-9 Molecular Weight 439.47
Density N/A Boiling Point N/A
Molecular Formula C25H21N5O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of A-933548


A-933548 is a potent Calpain inhibitor. A-933548 features enhanced selectivity versus related cysteine protease cathepsins, favorable microsomal stability, and efficacy in cellular assays.

 Names

Name A-933548

 A-933548 Biological Activity

Description A-933548 is a potent Calpain inhibitor. A-933548 features enhanced selectivity versus related cysteine protease cathepsins, favorable microsomal stability, and efficacy in cellular assays.
References 1. Kling A, Jantos K, Mack H, Hornberger W, Drescher K, Nimmrich V, Relo A, Wicke K, Hutchins CW, Lao Y, Marsh K, Moeller A. Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides. J Med Chem. 2017 Aug 24;60(16):7123-7138. doi: 10.1021/acs.jmedchem.7b00731. Epub 2017 Aug 15. PubMed PMID: 28759231.

 Chemical & Physical Properties

Molecular Formula C25H21N5O3
Molecular Weight 439.47
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