Saccharopine
Saccharopine structure
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Common Name | Saccharopine | ||
|---|---|---|---|---|
| CAS Number | 997-68-2 | Molecular Weight | 276.28600 | |
| Density | 1.333g/cm3 | Boiling Point | 537.2ºC at 760mmHg | |
| Molecular Formula | C11H20N2O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 278.7ºC | |
Use of SaccharopineSaccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis[1][2][3]. |
| Name | L-saccharopine |
|---|---|
| Synonym | More Synonyms |
| Description | Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis[1][2][3]. |
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| Related Catalog | |
| In Vitro | Saccharopine accumulation leads to mitochondrial damage and functional loss which is induced by saccharopine dehydrogenase (SDH) mutations of α-aminoadipate semialdehyde synthase (AASS)-1 in C. elegans[1]. |
| In Vivo | Saccharopine accumulation induces mitochondrial damage and progressive postnatal growth retardation in Aass mutant mice[1]. |
| References |
| Density | 1.333g/cm3 |
|---|---|
| Boiling Point | 537.2ºC at 760mmHg |
| Molecular Formula | C11H20N2O6 |
| Molecular Weight | 276.28600 |
| Flash Point | 278.7ºC |
| Exact Mass | 276.13200 |
| PSA | 149.95000 |
| LogP | 0.56740 |
| Index of Refraction | 1.537 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2922499990 |
| Precursor 0 | |
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| DownStream 2 | |
CAS#:56-87-1
CAS#:64-15-3| HS Code | 2922499990 |
|---|---|
| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
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Attenuation of autophagic-proteolysis in C2C12 cells by saccharopine.
Mol. Cell Biochem. 410 , 93-100, (2015) Muscle wasting impairs physical function and leads people to a bedridden state. We previously demonstrated that lysine (Lys) suppresses autophagic-proteolysis through the Akt pathway. However, the eff... |
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Molecular cloning and expression of human L-pipecolate oxidase.
Biochem. Biophys. Res. Commun. 270(3) , 1101-5, (2000) In higher eukaryotes L-lysine can be degraded via two distinct routes including the saccharopine pathway and the L-pipecolate pathway. The saccharopine pathway is the primary route of degradation of l... |
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Lysine catabolism in Haemonchus contortus and Teladorsagia circumcincta.
Exp. Parasitol. 131(1) , 101-6, (2012) Catabolism of lysine through the pipecolate, saccharopine and cadaverine pathways has been investigated in L3 and adult Haemonchus contortus and Teladorsagia circumcincta. Both enzymes of the saccharo... |
| L-SACCHAROPINE |
| L-Saccharopine |
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