Name | L-saccharopine |
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Synonyms |
L-SACCHAROPINE
L-Saccharopine |
Description | Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis[1][2][3]. |
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Related Catalog | |
In Vitro | Saccharopine accumulation leads to mitochondrial damage and functional loss which is induced by saccharopine dehydrogenase (SDH) mutations of α-aminoadipate semialdehyde synthase (AASS)-1 in C. elegans[1]. |
In Vivo | Saccharopine accumulation induces mitochondrial damage and progressive postnatal growth retardation in Aass mutant mice[1]. |
References |
Density | 1.333g/cm3 |
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Boiling Point | 537.2ºC at 760mmHg |
Molecular Formula | C11H20N2O6 |
Molecular Weight | 276.28600 |
Flash Point | 278.7ºC |
Exact Mass | 276.13200 |
PSA | 149.95000 |
LogP | 0.56740 |
Index of Refraction | 1.537 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
HS Code | 2922499990 |
HS Code | 2922499990 |
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Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |