Nebivolol
Modify Date: 2024-01-09 11:00:32
Nebivolol structure
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Common Name | Nebivolol | ||
|---|---|---|---|---|
| CAS Number | 99200-09-6 | Molecular Weight | 405.43500 | |
| Density | 1.309 g/cm3 | Boiling Point | 600.5ºC at 760 mmHg | |
| Molecular Formula | C22H25F2NO4 | Melting Point | 155-156°C(lit.) | |
| MSDS | N/A | Flash Point | 316.9ºC | |
Use of Nebivolol(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity[1][2]. |
| Name | 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] |
|---|---|
| Synonym | More Synonyms |
| Description | (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity[1][2]. |
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| Related Catalog | |
| Target |
IC50: 0.8 nM (β1-adrenergic receptor)[1] |
| In Vivo | Nebivolol (10 mg/kg; daily for 7 days) markedly improves endothelial dysfunction and increases P-VASP levels; prevents NOS III uncoupling; significantly inhibit NADPH oxidase in Angiotensin II-treated rats[3]. |
| References |
| Density | 1.309 g/cm3 |
|---|---|
| Boiling Point | 600.5ºC at 760 mmHg |
| Melting Point | 155-156°C(lit.) |
| Molecular Formula | C22H25F2NO4 |
| Molecular Weight | 405.43500 |
| Flash Point | 316.9ºC |
| Exact Mass | 405.17500 |
| PSA | 70.95000 |
| LogP | 2.75450 |
| Index of Refraction | 1.58 |
| Storage condition | 20°C |
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~51%
Nebivolol CAS#:99200-09-6 |
| Literature: EGIS GYOGYSZERGYAR RT. Patent: WO2004/41805 A1, 2004 ; Location in patent: Page 69 ; |
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~%
Nebivolol CAS#:99200-09-6 |
| Literature: WO2011/98474 A1, ; |
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~%
Nebivolol CAS#:99200-09-6 |
| Literature: WO2011/98474 A1, ; |
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Nebivolol CAS#:99200-09-6 |
| Literature: WO2011/98474 A1, ; |
![N-[(S,S)-1-hydroxy-2-(6-fluoro-chroman-4-one-2-yl)]-N-[(R,S)-1-hydroxy-2-(6-fiuoro-chroman-4-one-2-yl)]-amine structure](https://www.chemsrc.com/caspic/229/682359-63-3.png)
![N-benzyl-N-[(R,R)-1-hydroxy-2-(6-fluoro-chroman-4-one-2-yl)]-N-[(S,R)-1-hydroxy-2-(6-fluoro-chroman-4-one-2-yl)]-amine structure](https://www.chemsrc.com/caspic/469/797054-41-2.png)
CAS#:9920-09-6| Nebivolol |
| MFCD00865796 |
| (S,R,R,R)-NEBIVOLOL-D2,15N HYDROCHLORIDE |
| Nibivolol |
| rac-nebivolol |
| NEBIVOLOLHCL |
| NEBIVOLOL HYDROCHLORIDE |
| NEBIVOLOL-D4 |