1,2-Dichloro-4-nitrobenzene

Modify Date: 2024-01-02 20:07:10

1,2-Dichloro-4-nitrobenzene Structure
1,2-Dichloro-4-nitrobenzene structure
 Common Name 1,2-Dichloro-4-nitrobenzene
CAS Number 99-54-7 Molecular Weight 191.999
Density 1.5±0.1 g/cm3 Boiling Point 255.5±0.0 °C at 760 mmHg
Molecular Formula C6H3Cl2NO2 Melting Point 39-41 °C(lit.)
MSDS Chinese USA Flash Point 123.9±0.0 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Names

Name 1,2-Dichloro-4-nitrobenzene
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 255.5±0.0 °C at 760 mmHg
Melting Point 39-41 °C(lit.)
Molecular Formula C6H3Cl2NO2
Molecular Weight 191.999
Flash Point 123.9±0.0 °C
Exact Mass 190.954086
PSA 45.82000
LogP 3.16
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.596
Stability Stable. Incompatible with strong oxidizing agents, strong bases.
Water Solubility 151 mg/L (20 ºC)
Freezing Point 30~31℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CZ5250000
CHEMICAL NAME :
Benzene, 1,2-dichloro-4-nitro-
CAS REGISTRY NUMBER :
99-54-7
BEILSTEIN REFERENCE NO. :
1818163
LAST UPDATED :
199710
DATA ITEMS CITED :
19
MOLECULAR FORMULA :
C6-H3-Cl2-N-O2
MOLECULAR WEIGHT :
192.00
WISWESSER LINE NOTATION :
WNR CG DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
953 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/m3/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1384 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
790 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>200 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 mg/m3/4H/17W-I
TOXIC EFFECTS :
Blood - thrombocytopenia Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
28 mg/m3/4H/21D-I
TOXIC EFFECTS :
Blood - eosinophilia Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases

MUTATION DATA

TEST SYSTEM :
Insect - Drosophila melanogaster
DOSE/DURATION :
200 ppm
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,677,1985 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H317-H319
Precautionary Statements P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful;N:Dangerousfortheenvironment;
Risk Phrases R22;R36;R51/53
Safety Phrases S26-S36/37-S61-S39
RIDADR 2811
WGK Germany 3
RTECS CZ5250000
Packaging Group III
Hazard Class 9
HS Code 29049085

 Synthetic Route

 Customs

HS Code 2904909090
Summary HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Articles26

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Rats were exposed to black tea (2.5% w/v) as their sole drinking liquid for either 1 day or 1 month, while controls were maintained on water. After this treatment period, all animals received a single...
Low glutathione S-transferase dogs.

Arch. Toxicol. 78(4) , 218-25, (2004)

Liver and kidney glutathione S-transferase (GST) activities to 1,2-dichloro-4-nitrobenzene (DCNB) as a substrate (GST-D activities) were measured in 280 dogs from five different breeders, and signific...
Mitogen-activated protein kinase p38b interaction with delta class glutathione transferases from the fruit fly, Drosophila melanogaster.

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 Synonyms

3,4-Dichloronitrobenzene
MFCD00007207
Benzene, 1,2-dichloro-4-nitro-
1,2-Dichloro-4-nitrobenzene
EINECS 202-764-2
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