(R)-Flesinoxan structure
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Common Name | (R)-Flesinoxan | ||
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CAS Number | 98206-10-1 | Molecular Weight | 415.45800 | |
Density | 1.271g/cm3 | Boiling Point | 635.8ºC at 760mmHg | |
Molecular Formula | C22H26FN3O4 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 338.3ºC |
Use of (R)-FlesinoxanFlesinoxan is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan also has effective anxiolytic/antidepressant effects[1][2][3]. |
Name | 4-fluoro-N-[2-[4-[(2S)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-5-yl]piperazin-1-yl]ethyl]benzamide |
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Synonym | More Synonyms |
Description | Flesinoxan is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan also has effective anxiolytic/antidepressant effects[1][2][3]. |
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Target |
5-HT1A Receptor:24 nM (EC50) |
In Vivo | Flesinoxan acts as a partial agonist at postsynaptic and as a full agonist at presynaptic 5-HT1A receptors. The capacity of Flesinoxan to antagonize the effect of 5-HT on CA3 pyramidal neurons was similar to that of 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT)[1]. The intravenous administration of Flesinoxan suppresses the firing activity of both CA3 pyramidal neurons and dorsal raphe 5-HT neurons. The acute brain penetration of [3H]Flesinoxan and [3H]8-OH-DPAT are determined. Nine minutes after intravenous administration, [3H]8-OH-DPAT reached significantly greater brain concentration than [3H]Flesinoxan[1]. Subcutaneous administration of Flesinoxan and 8-OH-DPAT produce a dose-dependent hypothermia. The Flesinoxan-induced hypothermia is significantly attenuated by prior administration of the non-selective 5-HT1A antagonist pindolol and the 5-HT1/2 antagonist methysergide. Similar degrees of hypothermia are achieved with 3 mg/kg of Flesinoxan and 0.5 mg/kg of 8-OH-DPAT. The maximal effect of Flesinoxan occurs 30 min later than that of 8-OH-DPAT and fades more slowly[1]. |
References |
Density | 1.271g/cm3 |
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Boiling Point | 635.8ºC at 760mmHg |
Molecular Formula | C22H26FN3O4 |
Molecular Weight | 415.45800 |
Flash Point | 338.3ºC |
Exact Mass | 415.19100 |
PSA | 74.27000 |
LogP | 1.90360 |
Index of Refraction | 1.585 |
~% (R)-Flesinoxan CAS#:98206-10-1 |
Literature: Tetrahedron Letters, , vol. 33, # 42 p. 6287 - 6290 |
~% (R)-Flesinoxan CAS#:98206-10-1 |
Literature: Tetrahedron Letters, , vol. 33, # 42 p. 6287 - 6290 |
~% (R)-Flesinoxan CAS#:98206-10-1 |
Literature: Tetrahedron Letters, , vol. 33, # 42 p. 6287 - 6290 |
~% (R)-Flesinoxan CAS#:98206-10-1 |
Literature: Tetrahedron Letters, , vol. 33, # 42 p. 6287 - 6290 |
~% (R)-Flesinoxan CAS#:98206-10-1 |
Literature: Tetrahedron Letters, , vol. 33, # 42 p. 6287 - 6290 |
~% (R)-Flesinoxan CAS#:98206-10-1 |
Literature: Tetrahedron Letters, , vol. 33, # 42 p. 6287 - 6290 |
unii-8hv9s83fny |