Bithionol

Modify Date: 2024-01-03 01:10:13

Bithionol Structure
Bithionol structure
Common Name Bithionol
CAS Number 97-18-7 Molecular Weight 356.052
Density 1.8±0.1 g/cm3 Boiling Point 444.7±45.0 °C at 760 mmHg
Molecular Formula C12H6Cl4O2S Melting Point 188°C
MSDS Chinese USA Flash Point 222.8±28.7 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Bithionol


Bithionol is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models.IC50 value:Target: anticaner agentBithionol caused dose dependent cytotoxicity against all ovarian cancer cell lines tested with IC50 values ranging from 19 μM - 60 μM. BT treatment resulted in cell cycle arrest at G1/M phase and increased ROS generation [1]. Both bithionol and bithionol sulphoxide demonstrated in vitro toxicity to Neoparamoeba spp. at all concentrations examined (0.1 to 10 mg l(-1) over 72 h), with a comparable toxicity to freshwater observed for both chemicals at concentrations > 5 mg l(-1) following a 72 h treatment [2].

 Names

Name bithionol
Synonym More Synonyms

 Bithionol Biological Activity

Description Bithionol is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models.IC50 value:Target: anticaner agentBithionol caused dose dependent cytotoxicity against all ovarian cancer cell lines tested with IC50 values ranging from 19 μM - 60 μM. BT treatment resulted in cell cycle arrest at G1/M phase and increased ROS generation [1]. Both bithionol and bithionol sulphoxide demonstrated in vitro toxicity to Neoparamoeba spp. at all concentrations examined (0.1 to 10 mg l(-1) over 72 h), with a comparable toxicity to freshwater observed for both chemicals at concentrations > 5 mg l(-1) following a 72 h treatment [2].
Related Catalog
References

[1]. Ayyagari VN, et al. Bithionol inhibits ovarian cancer cell growth in vitro - studies on mechanism(s) of action. BMC Cancer. 2014 Feb 4;14:61.

[2]. Florent RL, et al. In vitro toxicity of bithionol and bithionol sulphoxide to Neoparamoeba spp., the causative agent of amoebic gill disease (AGD). Dis Aquat Organ. 2010 Sep 17;91(3):257-62.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 444.7±45.0 °C at 760 mmHg
Melting Point 188°C
Molecular Formula C12H6Cl4O2S
Molecular Weight 356.052
Flash Point 222.8±28.7 °C
Exact Mass 353.884247
PSA 65.76000
LogP 5.51
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.741
Storage condition 0-6°C
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility <0.1 g/100 mL at 23 ºC

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SN0525000
CHEMICAL NAME :
Phenol, 2,2'-thiobis(4,6-dichloro-
CAS REGISTRY NUMBER :
97-18-7
BEILSTEIN REFERENCE NO. :
2003535
LAST UPDATED :
199710
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C12-H6-Cl4-O2-S
MOLECULAR WEIGHT :
356.04
WISWESSER LINE NOTATION :
QR BG DG FSR BQ CG EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
760 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,612,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01763 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB223-159

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases S28-S36/37-S45-S36
RIDADR UN 2811 6.1/PG 2
WGK Germany 3
RTECS SN0525000
Packaging Group II
Hazard Class 6.1(a)
HS Code 2930909090

 Synthetic Route

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Bithionol Structure

Bithionol

CAS#:97-18-7

Literature: DE583055 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 20, p. 426

~%

Bithionol Structure

Bithionol

CAS#:97-18-7

Literature: DE583055 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 20, p. 426

~%

Bithionol Structure

Bithionol

CAS#:97-18-7

Literature: DE583055 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 20, p. 426

 Customs

HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles29

More Articles
An improved thyroid hormone reporter assay to determine the thyroid hormone-like activity of amiodarone, bithionol, closantel and rafoxanide.

Toxicol. Lett. 208(1) , 30-5, (2012)

A number of environmental chemicals have been reported to exhibit thyroid hormone-like activity. Since thyroid hormones play a crucial role in development, it is important to identify chemicals in the...

Determination of bithionol, bromophen, nitroxynil, oxyclozanide, and tribromsalan in milk with liquid chromatography coupled with tandem mass spectrometry.

J. AOAC Int. 93(4) , 1340-6, (2010)

LC/MS/MS was developed to determine the residues of bithionol (BTN), bromofen (BMF), nitroxynil (NTX), oxyclozanide (OCZ), and tribromsalan (TBS) in milk. Samples were extracted with ethyl acetate and...

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease.

Neurobiol. Dis. 74 , 144-57, (2015)

Aβ accumulation plays a central role in the pathogenesis of Alzheimer's disease (AD). Recent studies suggest that the process of Aβ nucleated polymerization is essential for Aβ fibril formation, patho...

 Synonyms

Phenol, 2,2'-thiobis(4,6-dichloro)-
Phenol, 2,2'-thiobis[4,6-dichloro-
Bitin
2-Hydroxy-3,5-dichlorophenyl sulfide
Bithionolate
2,2'-Thiobis[4,6-dichlorophenol]
2,2-DIMETHYL-7-ETHOXY-6-METHOXY-4-CHROMANONE
MFCD00055727
2,2'-Sulfanediylbis(4,6-dichlorophenol)
Bidiphen
2,2'-Thiobis- (4,6-dichlorophenol)
2,2’-thiobis[4,6-dichlorophenol]
Bithionol sulfide
Bithin
EINECS 202-565-0
2,2'-Thio-bis(4,6-dichlorophenol)
2,2'-Thiobis(4,6-dichlorophenol)
Bithionol
2,2'-Sulfanediylbis(4,6-dichlorphenol)
2,2’-sulfanediylbis(4,6-dichlorophenol)
Bitionol
Bis(2-hydroxy-3,5-dichlorophenyl)sulfide
2-Hydroxy-3,5-dichlorophenyl sulphide
2,4-dichloro-6-(3,5-dichloro-2-hydroxyphenyl)sulfanylphenol
bis (2-hydroxy-3,5-dichlorophenyl)-sulphide
bis(3,5-dichloro-2-hydroxy phenyl)-sulfide
Phenol, 2,2'-thiobis 4,6-dichloro-
2,2’-thiobis(4,6-dichlorophenol)
Lorothidol
Actamer
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  • Product Name: Bithionol
  • Price: $Inquiry/25mg $Inquiry/50mg $Inquiry/250mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao



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