Orlistat

Modify Date: 2024-01-02 17:43:07

Orlistat structure	Common Name	Orlistat
	CAS Number	96829-58-2	Molecular Weight	495.735
	Density	1.0±0.1 g/cm3	Boiling Point	615.9±30.0 °C at 760 mmHg
	Molecular Formula	C₂₉H₅₃NO₅	Melting Point	<50ºC
	MSDS	Chinese USA	Flash Point	326.3±24.6 °C

Use of Orlistat

Orlistat is a lipase inhibitor for obesity management that acts by inhibiting the absorption of dietary fats.

Name	[(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate
Synonym	More Synonyms

Description	Orlistat is a lipase inhibitor for obesity management that acts by inhibiting the absorption of dietary fats.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS) Research Areas >> Metabolic Disease
References	[1]. Zhi J, et al. Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers. J Clin Pharmacol. 1995 Nov;35(11):1103-8. [2]. Padwal R, et al. Long-term pharmacotherapy for obesity and overweight. Cochrane Database Syst Rev. 2004;(3):CD004094. [3]. Zhang E, et al. Glycycoumarin Sensitizes Liver Cancer Cells to ABT-737 by Targeting De Novo Lipogenesis and TOPK-Survivin Axis. Nutrients. 2018 Mar 15;10(3). pii: E353.

Description

Orlistat is a lipase inhibitor for obesity management that acts by inhibiting the absorption of dietary fats.

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS)

Research Areas >> Metabolic Disease

References

[1]. Zhi J, et al. Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers. J Clin Pharmacol. 1995 Nov;35(11):1103-8.

[2]. Padwal R, et al. Long-term pharmacotherapy for obesity and overweight. Cochrane Database Syst Rev. 2004;(3):CD004094.

[3]. Zhang E, et al. Glycycoumarin Sensitizes Liver Cancer Cells to ABT-737 by Targeting De Novo Lipogenesis and TOPK-Survivin Axis. Nutrients. 2018 Mar 15;10(3). pii: E353.

Density	1.0±0.1 g/cm3
Boiling Point	615.9±30.0 °C at 760 mmHg
Melting Point	<50ºC
Molecular Formula	C₂₉H₅₃NO₅
Molecular Weight	495.735
Flash Point	326.3±24.6 °C
Exact Mass	495.392365
PSA	81.70000
LogP	8.94
Appearance of Characters	solid \| white
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.470
Storage condition	2-8°C
Water Solubility	DMSO: 19 mg/mL

Orlistat MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	OH3167600

Precursor 0
DownStream 7
CAS#:130676-63-0 (7E,10S)-7-Heni... CAS#:130676-64-1 (2S)-5-hexyl-2-... CAS#:130676-66-3 Orlistat Open R... CAS#:130793-26-9 (3S,4R,6S)-3-He...
CAS#:130793-27-0 N-Formyl-L-leuc... CAS#:130676-65-2 N-Formyl-L-leuc... CAS#:68711-41-1 [S-(E)]-7-Henei...

Orlistat and calcium oxalate crystalluria: an association that needs consideration.

Ren. Fail. 32(8) , 1019-21, (2010)

Obesity is currently an epidemic across the globe. Obese patients unable to achieve significant weight loss with lifestyle changes alone may require drug therapy. Clinical trials have shown that orlis...

Orlistat-induced oxalate nephropathy may be dose-independent and present as a late manifestation.

J. La. State Med. Soc. 165(5) , 283-5, (2013)

We present the case of a 61-year-old Caucasian male veteran who had been on orlistat (120mg dosing) for four years, and had changed to the over-the-counter (OTC) form, Alli (orlistat 60mg), about thre...

Mechanisms of cholesterol and saturated fatty acid lowering by Quillaja saponaria extract, studied by in vitro digestion model.

Food Funct. 6 , 1319-30, (2015)

Quillaja saponin extracts are known to reduce plasma cholesterol levels in humans. Here we study the mechanism of this effect with Quillaja Dry saponin extract (QD). In vitro model of triglyceride lip...

[2S-[2a(R*),3b]]-N-Formyl-L-leucine 1-[(3-hexyl-4-oxo-2-oxetanyl)methyl]dodecyl ester

(−)-Tetrahydrolipstatin

N-Formyl-L-leucine ester with (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]-2-oxetanone

(2S)-1-[(2S,3S)-3-Hexyl-4-oxo-2-oxetanyl]-2-tridecanyl N-formyl-L-leucinate

Tetrahydrolipstatin

MFCD05662360

(2S)-1-[(2S,3S)-3-Hexyl-4-oxooxetan-2-yl]tridecan-2-yl N-formyl-L-leucinate

Alli

(1S)-1-{[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]methyl}dodecyl N-formyl-L-leucinate

Orlistat

(1S)-1-{[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]methyl}dodecyl (2S)-2-(formylamino)-4-methylpentanoate

Orlipastat

Orlipastatum

L-Leucine, N-formyl-, (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester

Xenical

(-)-Tetrahydrolipstatin

THLP

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Orlistat
Price: ￥268.0/5g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Orlistat (Alli, Xenical)
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Orlistat
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Xenical Orlistat
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Orlistat
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Orlistat suppliers

Price: $66/10mM*1mLinDMSO

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Orlistat

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