Daprodustat

Modify Date: 2024-01-02 16:48:38

Daprodustat Structure
Daprodustat structure
Common Name Daprodustat
CAS Number 960539-70-2 Molecular Weight 393.434
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C19H27N3O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Daprodustat


Daprodustat (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase inhibitor being developed for the treatment of anemia associated with chronic kidney disease.

 Names

Name Daprodustat
Synonym More Synonyms

 Daprodustat Biological Activity

Description Daprodustat (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase inhibitor being developed for the treatment of anemia associated with chronic kidney disease.
Related Catalog
In Vitro GSK1278863 is an orally administered small-molecule PHI, and stimulates endogenous EPO synthesis and induce effective erythropoiesis[1]. GSK1278863 has been shown to increase erythropoietin levels, leading to increases in hemoglobin, hematocrit and red blood cell numbers[2].
References

[1]. Brigandi RA, et al. A Novel Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor (GSK1278863) for Anemia in CKD: A 28-Day, Phase 2A Randomized Trial. Am J Kidney Dis. 2016 Jun;67(6):861-71

[2]. Hara K, et al. Pharmacokinetics, pharmacodynamics and safety of single, oral doses of GSK1278863, a novel HIF-prolyl hydroxylase inhibitor, in healthy Japanese and Caucasian subjects. Drug Metab Pharmacokinet. 2015 Dec;30(6):410-8

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C19H27N3O6
Molecular Weight 393.434
Exact Mass 393.189972
PSA 124.09000
LogP 0.86
Appearance of Characters white solid
Index of Refraction 1.580
Storage condition -20℃

 Synonyms

N-[(1,3-Dicyclohexyl-2,4,6-trioxohexahydro-5-pyrimidinyl)carbonyl]glycine
(1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carbonyl)glycine
GSK-1278863
Glycine, N-[(1,3-dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl]-
UNII:JVR38ZM64B
daprodustat
2-(1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carboxamido)acetic acid
GSK1278863
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