NIH-12848
Modify Date: 2025-08-25 10:53:50
NIH-12848 structure
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Common Name | NIH-12848 | ||
|---|---|---|---|---|
| CAS Number | 959551-10-1 | Molecular Weight | 385.412 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H14F3N3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NIH-12848NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM. |
| Name | NIH-12848 |
|---|---|
| Synonym | More Synonyms |
| Description | NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM. |
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| Related Catalog | |
| Target |
IC50: 1 μM (PI5P4Kγ)[1] |
| In Vitro | NIH-12848 inhibits PI5P4Kγ with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. NIH-12848 inhibits the translocation of Na+/ K+-ATPase to the plasma membrane that occurs when mpkCCD cells grow to confluence and also prevents reversibly their forming of ‘domes’ on the culture dish. Both these NIH-12848-induced effects are mimicked by specific RNAi knockdown of PI5P4Kγ, but not that of PI5P4Ks α or β. NIH-12848 could be a potentially powerful tool for exploring the cell physiology of PI5P4Ks[1]. |
| References |
| Molecular Formula | C20H14F3N3S |
|---|---|
| Molecular Weight | 385.412 |
| Appearance of Characters | white solid |
| InChIKey | QBDAEJRHUCSSPR-UHFFFAOYSA-N |
| SMILES | FC(F)(F)c1ccccc1-c1nc(NCc2cccs2)c2ccccc2n1 |
| Storage condition | -20℃ |
| N-(thiophen-2-ylmethyl)-2-(2-(trifluoromethyl)phenyl)quinazolin-4-amine |