959551-10-1

959551-10-1 structure

Name: NIH-12848
Chemical Name: NIH-12848
CAS Number: 959551-10-1
Molecular Formula: C₂₀H₁₄F₃N₃S
Molecular Weight: 385.412
Catalog: Research Areas Cardiovascular Disease
Create Date: 2018-05-02 03:38:00
Modify Date: 2024-01-05 19:22:38
NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM.

Name	NIH-12848
Synonyms	N-(thiophen-2-ylmethyl)-2-(2-(trifluoromethyl)phenyl)quinazolin-4-amine

Description	NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease
Target	IC50: 1 μM (PI5P4Kγ)[1]
In Vitro	NIH-12848 inhibits PI5P4Kγ with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. NIH-12848 inhibits the translocation of Na+/ K+-ATPase to the plasma membrane that occurs when mpkCCD cells grow to confluence and also prevents reversibly their forming of ‘domes’ on the culture dish. Both these NIH-12848-induced effects are mimicked by specific RNAi knockdown of PI5P4Kγ, but not that of PI5P4Ks α or β. NIH-12848 could be a potentially powerful tool for exploring the cell physiology of PI5P4Ks[1].
References	[1]. Clarke JH, et al. The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site. Biochem J. 2015 Mar 1;466(2):359-67.