2,4-Diaminotoluene

Modify Date: 2024-01-05 23:30:11

2,4-Diaminotoluene Structure
2,4-Diaminotoluene structure
 Common Name 2,4-Diaminotoluene
CAS Number 95-80-7 Molecular Weight 122.168
Density 1.1±0.1 g/cm3 Boiling Point 292.0±0.0 °C at 760 mmHg
Molecular Formula C7H10N2 Melting Point 97-99 °C(lit.)
MSDS Chinese USA Flash Point 149.5±21.3 °C
Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09		 Signal Word Danger

 Names

Name 2,4-diaminotoluene
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 292.0±0.0 °C at 760 mmHg
Melting Point 97-99 °C(lit.)
Molecular Formula C7H10N2
Molecular Weight 122.168
Flash Point 149.5±21.3 °C
Exact Mass 122.084396
PSA 52.04000
LogP 0.15
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.636
Water Solubility 50 g/l (25 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XS9625000
CHEMICAL NAME :
Toluene-2,4-diamine
CAS REGISTRY NUMBER :
95-80-7
BEILSTEIN REFERENCE NO. :
2205839
LAST UPDATED :
199712
DATA ITEMS CITED :
64
MOLECULAR FORMULA :
C7-H10-N2
MOLECULAR WEIGHT :
122.19
WISWESSER LINE NOTATION :
ZR CZ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
325 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Cardiac - pulse rate Lungs, Thorax, or Respiration - respiratory stimulation
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
480 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2100 mg/kg/90W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8050 mg/kg/101W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - lymphoma, including Hodgkin's disease
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
17 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - lymphoma, including Hodgkin's disease
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5030 mg/kg/84W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - lymphoma, including Hodgkin's disease
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9000 mg/kg/36W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8400 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16800 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1260 mg/kg
SEX/DURATION :
male 10 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1260 mg/kg
SEX/DURATION :
male 10 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
210 mg/kg
SEX/DURATION :
male 1 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1200 mg/kg
SEX/DURATION :
female 6-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Newborn - live birth index (measured after birth)
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
DNA adduct
TYPE OF TEST :
DNA damage
TYPE OF TEST :
Unscheduled DNA synthesis
TYPE OF TEST :
DNA inhibition
TYPE OF TEST :
Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Ovary
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 135,115,1984 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,83,1978 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,83,1978 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-RUSSIA:STEL 2 mg/m3;Skin JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO TOLUENEDIAMINE-air:CA lowest feasible concentration REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5386 No. of Facilities: 130 (estimated) No. of Industries: 6 No. of Occupations: 15 No. of Employees: 8511 (estimated) No. of Female Employees: 396 (estimated)

 Safety Information

Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09
Signal Word Danger
Hazard Statements H301-H312-H317-H341-H350-H361f-H373-H411
Precautionary Statements P201-P273-P280-P301 + P310-P308 + P313
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T:Toxic
Risk Phrases R21;R25;R36;R43;R45;R51/53
Safety Phrases S53-S45-S61
RIDADR UN 1709 6.1/PG 3
WGK Germany 3
RTECS XS9625000
Packaging Group III
Hazard Class 6.1(b)
HS Code 29331990

 Synthetic Route

 Customs

HS Code 2921519020
Summary 2921519020 4-methylbenzene-1,3-diamine。supervision conditions:x(environment control release notice for poisonous chemicals)。VAT:17.0%。tax rebate rate:17.0%。MFN tarrif:6.5%。general tariff:30.0%

 Articles28

More Articles
Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals.

Eur. J. Med. Chem. 44 , 3658-64, (2009)

A dataset comprising 55 chemicals with hepatocarcinogenic potency indices was collected from the Carcinogenic Potency Database with the aim of developing QSAR models enabling prediction of the above u...

Consumer product in vitro digestion model: Bioaccessibility of contaminants and its application in risk assessment.

Regul Toxicol Pharmacol 44(2) , 161-71, (2006)

This paper describes the applicability of in vitro digestion models as a tool for consumer products in (ad hoc) risk assessment. In current risk assessment, oral bioavailability from a specific produc...

JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for the detection of genotoxic carcinogens: I. Summary of pre-validation study results.

Mutat. Res. Genet. Toxicol. Environ. Mutagen. 786-788 , 3-13, (2015)

The in vivo rodent alkaline comet assay (comet assay) is used internationally to investigate the in vivo genotoxic potential of test chemicals. This assay, however, has not previously been formally va...

 Synonyms

1,3-Benzenediamine, 4-methyl-
4-Methylbenzene-1,3-diamine
2,4-TDA
tertralg
2,4-TOLUENEDIAMINE
4-Methyl-1,3-benzenediamine
2,4-diamino-toluene
Fouramine
EINECS 202-453-1
Toluene-2,4-diamine
1,3-diamino-4-methyl-benzene
MFCD00007804
UNII-IS1AKN4HYB
2,4-Diaminotoluene
2,4-toluylenediamine
Top Suppliers:I want be here

Get all suppliers and price by the below link:

2,4-Diaminotoluene suppliers

2,4-Diaminotoluene price

Related Compounds: More...
2,4-Diaminotoluene.2HCl
636-23-7
2,4-DIAMINOTOLUENE SULFATE
13616-82-5
2,4-Diaminotoluene sulfate
74283-36-6
5-chloro-2,4-diaminotoluene
43216-72-4
hexahydro-2,4-diaminotoluene
13897-55-7
5-tert-butyl-2,4-diaminotoluene
103490-01-3
2,4/2,6-Diaminotoluene
25376-45-8
2,4-ditert-butyl-6-(1,3-dihydrobenzimidazol-2-ylidene)cyclohexa-2,4-dien-1-one
810669-72-8
2-(4-methylbenzo[h]quinolin-2-yl)sulfanylaniline
81008-86-8
N-methyl-1-(2,4,6-trimethoxyphenyl)cyclopropan-1-amine
2228376-11-0
2-Amino-3-(3-fluoro-4-methylphenyl)-2-methylpropan-1-ol
2228205-41-0
1-(4-Chloro-2,5-difluorophenyl)-2,2-difluorocyclopropane-1-carboxylic acid
2228360-71-0
3-Amino-2-(4-ethynylphenyl)-2-methylpropan-1-ol
2228369-12-6
3-Hydroxy-1-[6-(trifluoromethyl)pyridin-3-yl]cyclobutane-1-carboxylic acid
2229251-66-3
5-(4-Amino-1,2-oxazol-5-yl)-2-nitrophenol
2228193-38-0
5-{6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl}-1,2-oxazol-3-amine
2229073-74-7
tert-butyl N-{2-[1-(methylamino)cyclopropyl]-5-(trifluoromethyl)phenyl}carbamate
2229595-46-2
1-(3-bromo-1-methyl-1H-pyrazol-5-yl)-3-oxocyclobutane-1-carbonitrile
2228195-62-6
(2S)-1-(4,5,6,7-tetrahydro-1H-indazol-3-yl)propan-2-amine
2227818-22-4
Chemsrc provides 2,4-Diaminotoluene(CAS#:95-80-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 2,4-Diaminotoluene are included as well.>> amp version: 2,4-Diaminotoluene

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved