Tumor Necrosis Factor-α, human

Modify Date: 2024-01-11 14:54:53

Tumor Necrosis Factor-α, human structure	Common Name	Tumor Necrosis Factor-α, human
	CAS Number	94948-59-1	Molecular Weight	691.86000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₂₁Cl₃N₆O₉	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Name	N-Propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-1H-imidazole-1-carbo xamide-2,4,7-trinitro-9H-fluoren-9-one (1:1)
Synonym	More Synonyms

Molecular Formula	C₂₈H₂₁Cl₃N₆O₉
Molecular Weight	691.86000
Exact Mass	690.04400
PSA	201.89000
LogP	8.79460
Storage condition	20°C

Tumor Necrosis Factor-α, human MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MT6435000

CHEMICAL NAME :: Human recombinant tumor necrosis factor-alpha

CAS REGISTRY NUMBER :: 94948-59-1

LAST UPDATED :: 199610

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 100 ug/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 1 ku/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 ku/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,1355,1991

Personal Protective Equipment	Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
RIDADR	NONH for all modes of transport
RTECS	MT6435000

Coordination complexes as molecular glue for immobilization of antibodies on cyclic olefin copolymer surfaces.

Anal. Biochem. 456 , 6-13, (2014)

A novel metal-based chelating method has been used to provide an order of magnitude increase in immunoassay performance on cyclic olefin copolymer (COC) plastics compared with passive binding. COCs ar...

Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation.

Sci. Signal. 8 , ra86, (2015)

Inflammatory critical illness is a syndrome that is characterized by acute inflammation and organ injury, and it is triggered by infections and noninfectious tissue injury, both of which activate inna...

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.

Cell Death Dis. 6 , e1767, (2015)

Necroptosis is a form of regulated necrotic cell death mediated by receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and RIPK3. Necroptotic cell death contributes to the pathophysiology o...

MFCD00148692

Tumor Necrosis Factor-α, human

Names

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Articles137

Synonyms