HSD-016

Modify Date: 2025-08-25 10:41:45

HSD-016 Structure
HSD-016 structure
 Common Name HSD-016
CAS Number 946396-92-5 Molecular Weight 514.45700
Density N/A Boiling Point N/A
Molecular Formula C21H21F7N2O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HSD-016


HSD-016 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 values of 11, 1 and 8 nM against human, mouse and rat 11β-HSD1, respectively. HSD-016 can be used for type 2 diabetes research[1].

 Names

Name (2R)-1,1,1-trifluoro-2-[3-[(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl]sulfonylphenyl]propan-2-ol
Synonym More Synonyms

 HSD-016 Biological Activity

Description HSD-016 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 values of 11, 1 and 8 nM against human, mouse and rat 11β-HSD1, respectively. HSD-016 can be used for type 2 diabetes research[1].
Related Catalog
Target

IC50: 1 nM (mouse 11β-HSD1), 8 nM (rat 11β-HSD1), 11 nM (human 11β-HSD1)[1]

References

[1]. Wan ZK, et al. Synthesis of potent and orally efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitor HSD-016. J Org Chem. 2011 Sep 2;76(17):7048-55.

 Chemical & Physical Properties

Molecular Formula C21H21F7N2O3S
Molecular Weight 514.45700
Exact Mass 514.11600
PSA 69.23000
LogP 5.59740
InChIKey ZWASRJHIEFYJGL-BFUOFWGJSA-N
SMILES CC1CN(c2ccc(F)cc2C(F)(F)F)CCN1S(=O)(=O)c1cccc(C(C)(O)C(F)(F)F)c1

 Synonyms

hsd-016
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Chemsrc provides HSD-016(CAS#:946396-92-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of HSD-016 are included as well.>> amp version: HSD-016

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