HSD-016

Names

[ Name ]:
HSD-016

[Synonym ]:
hsd-016

Biological Activity

[Description]:

HSD-016 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 values of 11, 1 and 8 nM against human, mouse and rat 11β-HSD1, respectively. HSD-016 can be used for type 2 diabetes research[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[Target]

IC50: 1 nM (mouse 11β-HSD1), 8 nM (rat 11β-HSD1), 11 nM (human 11β-HSD1)[1]

[References]

[1]. Wan ZK, et al. Synthesis of potent and orally efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitor HSD-016. J Org Chem. 2011 Sep 2;76(17):7048-55.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₁F₇N₂O₃S

[ Molecular Weight ]:
514.45700

[ Exact Mass ]:
514.11600

[ PSA ]:
69.23000

[ LogP ]:
5.59740

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.