LX-1031
Modify Date: 2024-04-05 16:37:07
LX-1031 structure
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Common Name | LX-1031 | ||
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| CAS Number | 945976-76-1 | Molecular Weight | 538.518 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 715.6±70.0 °C at 760 mmHg | |
| Molecular Formula | C28H25F3N4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 386.6±35.7 °C | |
Use of LX-1031LX-1031 is a potent, orally available tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally. |
| Name | (2S)-2-amino-3-[4-[2-amino-6-[(1R)-2,2,2-trifluoro-1-[4-(3-methoxyphenyl)phenyl]ethoxy]pyrimidin-4-yl]phenyl]propanoic acid |
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| Synonym | More Synonyms |
| Description | LX-1031 is a potent, orally available tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally. |
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| Related Catalog | |
| In Vivo | With oral administration of LX-1031 in mice, the average 5-HT reductions in the jejunum relative to control are appr 33, 51, and 66% with the 15, 45 and 135 mg/kg/day doses respectively. In a preliminary report, the effects of LX-1031, 100 mg/kg daily, on 5-HT levels in jejunal mucosa are reversible within 2 days of discontinuation in mice[1]. LX-1031 dose-dependently reduces expression of 5-HT in the duodenum, jejunum and ileum, but has no effect on brain 5-HT levels in preclinical assay[2]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 715.6±70.0 °C at 760 mmHg |
| Molecular Formula | C28H25F3N4O4 |
| Molecular Weight | 538.518 |
| Flash Point | 386.6±35.7 °C |
| Exact Mass | 538.182800 |
| PSA | 134.31000 |
| LogP | 5.36 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.608 |
| Storage condition | 2-8℃ |
| unii-j08e1j78gk |
| 4-{2-Amino-6-[(1R)-2,2,2-trifluoro-1-(3'-methoxy-4-biphenylyl)ethoxy]-4-pyrimidinyl}-L-phenylalanine |
| cs-0452 |
| lx-1031 |
| lx-1031||lx 1031 |
| L-Phenylalanine, 4-[2-amino-6-[(1R)-2,2,2-trifluoro-1-(3'-methoxy[1,1'-biphenyl]-4-yl)ethoxy]-4-pyrimidinyl]- |