Tolvaptan phosphate ester sodium

Modify Date: 2024-02-11 18:50:13

Tolvaptan phosphate ester sodium structure	Common Name	Tolvaptan phosphate ester sodium
	CAS Number	942619-79-6	Molecular Weight	572.88
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₄ClN₂Na₂O₆P	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Tolvaptan phosphate ester sodium

Tolvaptan phosphate ester sodium, a prodrug of Tolvaptan (HY-17000), can be used in the study of cardiac edema. Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation[1][2].

Name	Tolvaptan phosphate ester sodium

Description	Tolvaptan phosphate ester sodium, a prodrug of Tolvaptan (HY-17000), can be used in the study of cardiac edema. Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor
References	[1]. Hiroyuki Fujiki, et al. In vitro and in vivo pharmacological profile of OPC-61815, a water-soluble phosphate ester pro-drug of tolvaptan. J Pharmacol Sci. 2022 Nov;150(3):163-172. [2]. Wu Y, et al. Mechanisms of tolvaptan-induced toxicity in HepG2 cells. Biochem Pharmacol. 2015 Jun 15;95(4):324-36.

Description

Related Catalog

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor

References

[1]. Hiroyuki Fujiki, et al. In vitro and in vivo pharmacological profile of OPC-61815, a water-soluble phosphate ester pro-drug of tolvaptan. J Pharmacol Sci. 2022 Nov;150(3):163-172.

[2]. Wu Y, et al. Mechanisms of tolvaptan-induced toxicity in HepG2 cells. Biochem Pharmacol. 2015 Jun 15;95(4):324-36.