Tolvaptan phosphate ester sodium

Names

[ Name ]:
Tolvaptan phosphate ester sodium

Biological Activity

[Description]:

Tolvaptan phosphate ester sodium, a prodrug of Tolvaptan (HY-17000), can be used in the study of cardiac edema. Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor

[References]

[1]. Hiroyuki Fujiki, et al. In vitro and in vivo pharmacological profile of OPC-61815, a water-soluble phosphate ester pro-drug of tolvaptan. J Pharmacol Sci. 2022 Nov;150(3):163-172.

[2]. Wu Y, et al. Mechanisms of tolvaptan-induced toxicity in HepG2 cells. Biochem Pharmacol. 2015 Jun 15;95(4):324-36.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₄ClN₂Na₂O₆P

[ Molecular Weight ]:
572.88

Related Compounds

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