R-G-E-S

Modify Date: 2025-08-22 18:57:02

R-G-E-S Structure
R-G-E-S structure
Common Name R-G-E-S
CAS Number 93674-97-6 Molecular Weight 447.44400
Density 1.61g/cm3 Boiling Point N/A
Molecular Formula C16H29N7O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of R-G-E-S


Arg-Gly-Glu-Ser is a RGD-related peptide and a control for the RGDS ihibitory activity on fibrinogen binding to activated platelets.

 Names

Name h-arg-gly-glu-ser-oh
Synonym More Synonyms

 R-G-E-S Biological Activity

Description Arg-Gly-Glu-Ser is a RGD-related peptide and a control for the RGDS ihibitory activity on fibrinogen binding to activated platelets.
Related Catalog
In Vivo Arg-Gly-Glu-Ser (5 mg/kg) in combination with LPS or saline + RGDS does not affect neutrophil and macrophage cell numbers and has no effect on protein accumulation compared with LPS- or saline-treated mice, respectively[1].
Animal Admin Mice[1] Mouse pharyngeal aspiration is performed in the assay. Animals are anesthetized with a mixture of ketamine and xylazine (45 mg/kg and 8 mg/kg, i.p., respectively). Test solution (30 μL) containing LPS (1.5 mg/kg) is placed posterior in the throat and aspirated into the lungs. Control mice are administrated sterile saline (0.9% NaCl). Animals are administered with RGDS or Arg-Gly-Glu-Ser peptide (1, 2.5 or 5 mg/kg, i.p.) once one hour before LPS treatment and sacrificed 4 h post-LPS. Animals are also administered RGDS or Arg-Gly-Glu-Ser peptide (5 mg/kg, i.p.) once at different time points (1 h before or 2 h after LPS treatment) and sacrificed 24 h post-LPS. In addition, animals are administered with αvβ3-blocking mAbs, anti-αv, or anti-β3 (5 mg/kg, i.p.) once 1 h before and sacrificed 4 h post-LPS. Animals administered with these mAbs 2 h after LPS treatment are sacrificed 24 h post-LPS[1].
References

[1]. Moon C, et al. Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir Res. 2009 Mar 9;10:18.

 Chemical & Physical Properties

Density 1.61g/cm3
Molecular Formula C16H29N7O8
Molecular Weight 447.44400
Exact Mass 447.20800
PSA 270.05000
Index of Refraction 1.649
Storage condition 2-8℃

 Safety Information

WGK Germany 3

 Synonyms

ARG-GLY-GLU-SER
rgespeptide
R-G-E-S
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