helospectin II
Modify Date: 2024-02-19 15:11:33
helospectin II structure
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Common Name | helospectin II | ||
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| CAS Number | 93585-83-2 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C180H288N46O57 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of helospectin IIHelospectin II is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin II has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin II is originally isolated from the salivary gland venom of the lizard Heloderma suspectum[1][2]. |
| Name | (4S)-5-[[(1S)-2-[[(1S)-2-[[(1S)-5-amino-1-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[(1S)-5-amino-1-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(1S)-4-amino-1-[[(1S)-5-amino-1-[[(1S)-2-[[(1S)-1-[[(1S)-3-carboxy-1-[[(1S)-2-[[(1S,2S)-1-[[(1S)-1-[[2-[[(1S)-2-[[(1S)-2-[[(1S,2R)-1-[[(1S)-2-[(2S)-2-[[(1S)-1-[(2S)-2-[(2S)-2-[[(1S)-1-carboxy-2-hydroxy-ethyl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carbonyl]-4-guanidino-butyl]carbamoyl]pyrrolidin-1-yl]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]-2-methyl-butyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]propyl]carbamoyl]-3-methyl-butyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]carbamoyl]pentyl]carbamoyl]-4-oxo-butyl]carbamoyl]-3-methyl-butyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]pentyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-methyl-butyl]carbamoyl]pentyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-4-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-propanoyl]amino]-3-carboxy-propanoyl]amino]propanoyl]amino]-3-hydroxy-butanoyl]amino]-3-phenyl-propanoyl]amino]-3-hydroxy-butanoyl]amino]propanoyl]amino]-5-oxo-pentanoic acid |
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| Description | Helospectin II is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin II has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin II is originally isolated from the salivary gland venom of the lizard Heloderma suspectum[1][2]. |
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| Related Catalog | |
| Target |
Vasoactive intestinal peptide (VIP) receptor[1] |
| In Vitro | Helospectin II (suffusion at 0.1 nM, in bicarbonate buffer for 30 min) evokes significant, sustained and similar vasodilation in the intact hamster cheek pouch[1]. Helospectin II relaxes the Phenylephrine-contracted rat femoral arteries with pEC50 of 6.93[2]. |
| In Vivo | Helospectin II (0.03-2 nmol/kg, 100 μL of infusion at the left jugular vein) reduces blood pressure in rats[2]. Animal Model: SD rats[2] Dosage: 0.03, 0.3, 1, 2 nmol/kg Administration: 100 μL of infusion at the left jugular vein, followed by washing the catheter with 100 μL saline. Result: Reduced the blood pressure, but was less effective than vasoactive intestinal peptide (VIP) in the low dose range. |
| References |
| Molecular Formula | C180H288N46O57 |
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