helospectin II

• 常用名: helospectin II
• 英文名: helospectin II
• CAS号: 93585-83-2
• 分子量: N/A
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈₀H₂₈₈N₄₆O₅₇
• 熔点: N/A
• 闪点: N/A

helospectin II用途

Helospectin II是血管活性肠肽(VIP)家族的一种神经肽。Helospectin II具有血管扩张和降压活性,并降低血压。Helospectin II最初是从疑似黑皮蜥蜴的唾液腺毒液中分离出来的[1][2]。

helospectin II名称

• 英文名: (4S)-5-[[(1S)-2-[[(1S)-2-[[(1S)-5-amino-1-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[(1S)-5-amino-1-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(1S)-4-amino-1-[[(1S)-5-amino-1-[[(1S)-2-[[(1S)-1-[[(1S)-3-carboxy-1-[[(1S)-2-[[(1S,2S)-1-[[(1S)-1-[[2-[[(1S)-2-[[(1S)-2-[[(1S,2R)-1-[[(1S)-2-[(2S)-2-[[(1S)-1-[(2S)-2-[(2S)-2-[[(1S)-1-carboxy-2-hydroxy-ethyl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carbonyl]-4-guanidino-butyl]carbamoyl]pyrrolidin-1-yl]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]-2-methyl-butyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]propyl]carbamoyl]-3-methyl-butyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]carbamoyl]pentyl]carbamoyl]-4-oxo-butyl]carbamoyl]-3-methyl-butyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]pentyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-methyl-butyl]carbamoyl]pentyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-4-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-propanoyl]amino]-3-carboxy-propanoyl]amino]propanoyl]amino]-3-hydroxy-butanoyl]amino]-3-phenyl-propanoyl]amino]-3-hydroxy-butanoyl]amino]propanoyl]amino]-5-oxo-pentanoic acid

helospectin II生物活性

• 描述: Helospectin II是血管活性肠肽(VIP)家族的一种神经肽。Helospectin II具有血管扩张和降压活性,并降低血压。Helospectin II最初是从疑似黑皮蜥蜴的唾液腺毒液中分离出来的[1][2]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 靶点:

  Vasoactive intestinal peptide (VIP) receptor[1]

• 体外研究: Helospectin II(0.1 nM,在碳酸氢盐缓冲液中浸泡30分钟)在完整的仓鼠颊袋中引起显著、持续和类似的血管扩张[1]。Helospectin II以6.93的pEC50放松苯基肾上腺素收缩的大鼠股动脉[2]。
• 体内研究: Helospectin II(0.03-2 nmol/kg,左颈静脉输注100μL)可降低大鼠血压[2]。动物模型：SD大鼠[2]剂量：0.03、0.3、1、2 nmol/kg给药：在左颈静脉输注100μL,然后用100μL盐水冲洗导管。结果：在低剂量范围内,降压效果低于血管活性肠肽(VIP)。
• 参考文献:

  [1]. Tsueshita T, et al. Helospectin I and II evoke vasodilation in the intact peripheral microcirculation. Peptides. 2004 Jan;25(1):65-9.

  [2]. Grundemar L, et al. Vascular effects of helodermin, helospectin I and helospectin II: a comparison with vasoactive intestinal peptide (VIP). Br J Pharmacol. 1990 Mar;99(3):526-8.

helospectin II物理化学性质

• 分子式: C₁₈₀H₂₈₈N₄₆O₅₇
• InChIKey: LKDLKXMXYPSIRO-ZXFPMOGVSA-N
• SMILES: CCC(C)C(NC(=O)C(CO)NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCCCN)NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(N)Cc1cnc[nH]1)C(C)O)C(C)O)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CO)C(=O)NC(C(=O)NC(CO)C(=O)N1CCCC1C(=O)NC(CCCNC(=N)N)C(=O)N1CCCC1C(=O)N1CCCC1C(=O)NC(CO)C(=O)O)C(C)O