Rabeprazole D4

Modify Date: 2024-01-08 15:33:22

Rabeprazole D4 Structure
Rabeprazole D4 structure
Common Name Rabeprazole D4
CAS Number 934295-48-4 Molecular Weight 359.44300
Density N/A Boiling Point N/A
Molecular Formula C18H17D4N3O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Rabeprazole D4


Rabeprazole D4 (LY307640 D4) is a deuterium labeled Rabeprazole. Rabeprazole is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].

 Names

Name 1H-Benzimidazole-4,5,6,7-d4, 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]
Synonym More Synonyms

 Rabeprazole D4 Biological Activity

Description Rabeprazole D4 (LY307640 D4) is a deuterium labeled Rabeprazole. Rabeprazole is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].
Related Catalog
Target

Pump inhibitor (PPI); UNH[1] H+/K+-ATPase; Apoptosis[2]

References

[1]. Tara A Shea, et al. Identification of Proton-Pump Inhibitor Drugs That Inhibit Trichomonas Vaginalis Uridine Nucleoside Ribohydrolase. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1080-4.

[2]. Mengli Gu, et al. Rabeprazole Exhibits Antiproliferative Effects on Human Gastric Cancer Cell Lines. Oncol Lett. 2014 Oct;8(4):1739-1744.

[3]. Aly A M Shaalan, et al. Supplement With Calcium or Alendronate Suppresses Osteopenia Due to Long Term Rabeprazole Treatment in Female Mice: Influence on Bone TRAP and Osteopontin Levels. Front Pharmacol. 2020 May 13;11:583.

 Chemical & Physical Properties

Molecular Formula C18H17D4N3O3S
Molecular Weight 359.44300
Exact Mass 359.13000
PSA 96.31000
LogP 3.85510

 Safety Information

Hazard Codes Xi

 Synonyms

Rabeprazole-d4
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