JMC-4

Modify Date: 2024-01-08 02:54:46

JMC-4 Structure
JMC-4 structure
Common Name JMC-4
CAS Number 93261-39-3 Molecular Weight 338.27
Density N/A Boiling Point N/A
Molecular Formula C17H10N2O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of JMC-4


1-Naphthyl 3,5-dinitrobenzoate is a potent 5-lipoxygenase inhibitor with IC50 values of 1.04 µM and 3.6 µM for 5-LOX and mPGES-1, respectively. 1-Naphthyl 3,5-dinitrobenzoate has strong inhibition activity in the human whole blood (HWB) assay with an IC50 value of 8.6 μM. 1-Naphthyl 3,5-dinitrobenzoate can be used in research of inflammation[1].

 Names

Name 1-Naphthyl 3,5-dinitrobenzoate
Synonym More Synonyms

 JMC-4 Biological Activity

Description 1-Naphthyl 3,5-dinitrobenzoate is a potent 5-lipoxygenase inhibitor with IC50 values of 1.04 µM and 3.6 µM for 5-LOX and mPGES-1, respectively. 1-Naphthyl 3,5-dinitrobenzoate has strong inhibition activity in the human whole blood (HWB) assay with an IC50 value of 8.6 μM. 1-Naphthyl 3,5-dinitrobenzoate can be used in research of inflammation[1].
Related Catalog
References

[1]. Wu Y, et, al. Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors. J Med Chem. 2012 Mar 22;55(6):2597-605.  

 Chemical & Physical Properties

Molecular Formula C17H10N2O6
Molecular Weight 338.27
Exact Mass 338.05400
PSA 117.94000
LogP 4.92180

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

3,5-Dinitro-benzoesaeure-tetrahydrofurfurylester
3,5-dinitro-benzoic acid-[1]naphthyl ester
2-(3,5-dinitro-benzoyloxymethyl)-tetrahydro-furan
3,5-dinitro-benzoic acid tetrahydrofurfuryl ester
tetrahydro-furfuryl alcohol
3,5-Dinitro-benzoesaeure-[1]naphthylester
2-Furanmethanol,tetrahydro-,3,5-dinitrobenzoate
3,5-Dinitro-benzoesaeure-naphthyl-(1)-ester