JMC-4

Names

[ Name ]:
JMC-4

[Synonym ]:
3,5-Dinitro-benzoesaeure-tetrahydrofurfurylester
3,5-dinitro-benzoic acid-[1]naphthyl ester
2-(3,5-dinitro-benzoyloxymethyl)-tetrahydro-furan
3,5-dinitro-benzoic acid tetrahydrofurfuryl ester
tetrahydro-furfuryl alcohol
3,5-Dinitro-benzoesaeure-[1]naphthylester
2-Furanmethanol,tetrahydro-,3,5-dinitrobenzoate
3,5-Dinitro-benzoesaeure-naphthyl-(1)-ester

Biological Activity

[Description]:

1-Naphthyl 3,5-dinitrobenzoate is a potent 5-lipoxygenase inhibitor with IC50 values of 1.04 µM and 3.6 µM for 5-LOX and mPGES-1, respectively. 1-Naphthyl 3,5-dinitrobenzoate has strong inhibition activity in the human whole blood (HWB) assay with an IC50 value of 8.6 μM. 1-Naphthyl 3,5-dinitrobenzoate can be used in research of inflammation[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

[References]

[1]. Wu Y, et, al. Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors. J Med Chem. 2012 Mar 22;55(6):2597-605.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₀N₂O₆

[ Molecular Weight ]:
338.27

[ Exact Mass ]:
338.05400

[ PSA ]:
117.94000

[ LogP ]:
4.92180

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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