DG70

Modify Date: 2025-09-29 11:21:18

DG70 structure	Common Name	DG70
	CAS Number	930470-97-6	Molecular Weight	385.82
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₇ClFNO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DG70

DG70 (GSK1733953A), a biphenyl amide, is a respiration inhibitor in Mycobacterium tuberculosis, inhibits MenG activity with an IC50 value of 2.6 ± 0.6 μM. DG70 inhibits the catalytic methylation of Mycobacterium tuberculosis demethylmenaquinone methyltransferase enzymes. DG70 can be used for Tuberculosis (TB) research[1][2][3].

Name	GSK1733953A

Description	DG70 (GSK1733953A), a biphenyl amide, is a respiration inhibitor in Mycobacterium tuberculosis, inhibits MenG activity with an IC50 value of 2.6 ± 0.6 μM. DG70 inhibits the catalytic methylation of Mycobacterium tuberculosis demethylmenaquinone methyltransferase enzymes. DG70 can be used for Tuberculosis (TB) research[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 2.6 ± 0.6 μM (MenG)[1]
References	[1]. Pujari V, et al. Mycobacterial MenG: Partial Purification, Characterization, and Inhibition. ACS Infect Dis. 2022 Dec 9;8(12):2430-2440. [2]. Adewumi AT, et al. Thompson loop: opportunities for antitubercular drug design by targeting the weak spot in demethylmenaquinone methyltransferase protein. RSC Adv. 2020 Jun 19;10(39):23466-23483. [3]. Sukheja P, et al. A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells. mBio. 2017 Feb 14;8(1):e02022-16.

Molecular Formula	C₂₁H₁₇ClFNO₃
Molecular Weight	385.82
Storage condition	2-8°C

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: DG70
Price: Check
Purity: 99.45%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Gsk1733953a
Price: ￥550.0/100mg ￥850.0/250mg ￥1800.0/1g ￥150.0/10ml
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: ￥550/25 mg

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DG70

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DG70 Biological Activity

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.