Jingzhaotoxin-III

Modify Date: 2025-09-26 17:44:22

Jingzhaotoxin-III structure	Common Name	Jingzhaotoxin-III
	CAS Number	925463-91-8	Molecular Weight	3919.45
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇₄H₂₄₁N₄₇O₄₆S₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Jingzhaotoxin-III

Jingzhaotoxin-III is a potent and selective blocker of Nav1.5 channels, with an IC50 of 348 nM, and shows no effect on other sodium channel isoforms. Jingzhaotoxin-III can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes, and hopefully represents an important ligand for discriminating cardiac VGSC subtype[1][2].

Name	Jingzhaotoxin-III

Description	Jingzhaotoxin-III is a potent and selective blocker of Nav1.5 channels, with an IC50 of 348 nM, and shows no effect on other sodium channel isoforms. Jingzhaotoxin-III can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes, and hopefully represents an important ligand for discriminating cardiac VGSC subtype[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
Target	IC50: 348 nM (Nav1.5 Channels)[1]
References	[1]. Rong M, et, al. Molecular basis of the tarantula toxin jingzhaotoxin-III (β-TRTX-Cj1α) interacting with voltage sensors in sodium channel subtype Nav1.5. FASEB J. 2011 Sep; 25(9): 3177-85. [2]. Xiao Y, et, al. Jingzhaotoxin-III, a novel spider toxin inhibiting activation of voltage-gated sodium channel in rat cardiac myocytes. J Biol Chem. 2004 Jun 18; 279(25): 26220-6.

Molecular Formula	C₁₇₄H₂₄₁N₄₇O₄₆S₆
Molecular Weight	3919.45

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Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.