Rp-8-bromo-Cyclic AMPS
Modify Date: 2023-01-30 16:07:22
Rp-8-bromo-Cyclic AMPS structure
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Common Name | Rp-8-bromo-Cyclic AMPS | ||
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| CAS Number | 925456-59-3 | Molecular Weight | 446.149 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H10BrN5O5PS.Na | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Rp-8-bromo-Cyclic AMPSRp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. |
| Name | Sodium (2R,4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-sulfide |
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| Synonym | More Synonyms |
| Description | Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. |
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| In Vitro | Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II from bovine heart. |
| Molecular Formula | C10H10BrN5O5PS.Na |
|---|---|
| Molecular Weight | 446.149 |
| Exact Mass | 444.922119 |
| Sodium (2R,4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-sulfide |
| 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin-7-ol, 6-(6-amino-8-bromo-9H-purin-9-yl)tetrahydro-2-mercapto-, 2-oxide, sodium salt, (4aR,6R,7R,7aS)- (1:1) |