BT18
Modify Date: 2025-09-18 14:12:45
BT18 structure
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Common Name | BT18 | ||
|---|---|---|---|---|
| CAS Number | 924811-53-0 | Molecular Weight | 637.64 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H31F4N3O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BT18BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF)[1]. BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function[2]. |
| Name | BT18 |
|---|
| Description | BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF)[1]. BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function[2]. |
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| Related Catalog | |
| In Vitro | BT18 (50 μM; 1-90 minutes) activates AKT and ERK1/2 in time-dependently in MG87RET cell lines[1]. BT18 (1-50 μM; 90 minutes) activates AKT in a dose-dependent manner in MG87RET cell lines[1]. BT18 (5-50 μM; 15 mimutes) appears to phosphorylate RET in concentration of 50 µM both in GFP-transfected and in GFRD1-transfected cells[1]. Western Blot Analysis[1] Cell Line: MG87RET cell lines Concentration: 50 μM Incubation Time: 1, 5, 15, 45, 90 minutes Result: Activated AKT and ERK1/2 in time-dependently. |
| References |
[1]. Leo Jakman, Characterization of small-molecule GDNF mimics. |
| Molecular Formula | C30H31F4N3O6S |
|---|---|
| Molecular Weight | 637.64 |
| InChIKey | QVIIZVVDZZHGCB-UHFFFAOYSA-N |
| SMILES | COc1cc2c(cc1OC)CN(S(=O)(=O)c1ccc(OC)c(N3CCN(C(=O)c4ccc(F)cc4C(F)(F)F)CC3)c1)CC2 |