Phenidone

Modify Date: 2024-01-02 14:26:27

Phenidone structure	Common Name	Phenidone
	CAS Number	92-43-3	Molecular Weight	162.189
	Density	1.2±0.1 g/cm3	Boiling Point	304.1±25.0 °C at 760 mmHg
	Molecular Formula	C₉H₁₀N₂O	Melting Point	119-121 °C(lit.)
	MSDS	Chinese USA	Flash Point	137.7±23.2 °C
	Symbol	GHS07, GHS09	Signal Word	Warning

Use of Phenidone

Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat[1][2]. Phenidone is used as a photographic developer[3].

Name	Phenidone
Synonym	More Synonyms

Description	Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat[1][2]. Phenidone is used as a photographic developer[3].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
Target	COX LOX
In Vitro	Phenidone significantly inhibits the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE)[1].
In Vivo	Phenidone inhibits the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat[2].
References	[1]. Moon C, et al. Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. Brain Res. 2005;1035(2):206-210. [2]. Stern N, et al. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. Am J Hypertens. 1993;6(1):52-58. [3]. Petrakiev A, et al. Emission spectral analysis using photographic plates treated with a phenidone developer. Talanta. 1969;16(12):1583-1587.

Density	1.2±0.1 g/cm3
Boiling Point	304.1±25.0 °C at 760 mmHg
Melting Point	119-121 °C(lit.)
Molecular Formula	C₉H₁₀N₂O
Molecular Weight	162.189
Flash Point	137.7±23.2 °C
Exact Mass	162.079315
PSA	32.34000
LogP	0.20
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.620
Stability	Stable, but light sensitive. Incompatible with strong acids, strong oxidizing agents, strong bases.
Water Solubility	SOLUBLE IN HOT WATER

Phenidone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ8750000

CHEMICAL NAME :: 3-Pyrazolidinone, 1-phenyl-

CAS REGISTRY NUMBER :: 92-43-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C9-H10-N2-O

MOLECULAR WEIGHT :: 162.21

WISWESSER LINE NOTATION :: T5NMVTJ AR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 309 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(9),87,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(1),49,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 287 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(9),87,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1310 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(9),87,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 986 mg/kg/61D-I

TOXIC EFFECTS :: Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(9),87,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0749 No. of Facilities: 1437 (estimated) No. of Industries: 14 No. of Occupations: 7 No. of Employees: 6865 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0749 No. of Facilities: 4414 (estimated) No. of Industries: 34 No. of Occupations: 37 No. of Employees: 51775 (estimated) No. of Female Employees: 25903 (estimated)

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H411
Precautionary Statements	P273
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful;N:Dangerousfortheenvironment;
Risk Phrases	R22;R51/53
Safety Phrases	S61
RIDADR	UN 2811 6.1/PG 3
WGK Germany	2
RTECS	UQ8750000
Packaging Group	III
Hazard Class	6.1
HS Code	2933199090

Precursor 8
CAS#:59-88-1 Phenylhydrazine... CAS#:140-88-5 Ethyl acrylate ... CAS#:100-63-0 Phenylhydrazine CAS#:3314-35-0 3-Amino-4,5-dih...
CAS#:41682-87-5 3-hydroxy-propi... CAS#:26955-79-3 3-(2-phenylhydr... CAS#:79-06-1 Acrylamide Crystals CAS#:5883-17-0 N-Ethylacrylamide
DownStream 6
CAS#:113410-22-3 4-(2-hydroxyeth... CAS#:2655-46-1 2-acetyl-1-phen... CAS#:65684-98-2 2-phenyl-5-(3,4... CAS#:58469-32-2 5-chloro-2-phen...
CAS#:60588-53-6 N-(3-oxo-1-phen... CAS#:61447-57-2 5-(4-fluorophen...

HS Code	2933199090
Summary	2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Antioxidant and Anti-inflammatory Activities of Essential Oil and Extracts of Piper miniatum.

Nat. Prod. Commun. 10 , 2005-8, (2016)

The chemical composition of the essential oil and antioxidant and anti-inflammatory activities of the extracts from Piper miniatum were determined. GC and GC-MS analysis of the essential oil resulted ...

Phenidone attenuates oxygen/glucose deprivation-induced neurotoxicity by antioxidant and antiapoptotic action in mouse cortical cultures.

Neurosci. Lett. 272(2) , 91-4, (1999)

The abrupt elevation in the levels of cyclooxygenase or lipoxygenase metabolites of arachidonic acid during cerebral ischemia contributes to neuronal injury. Recently, evidence has accumulated that bo...

The role of jasmonates in floral nectar secretion.

PLoS ONE 5(2) , e9265, (2010)

Plants produce nectar in their flowers as a reward for their pollinators and most of our crops depend on insect pollination, but little is known on the physiological control of nectar secretion. Jasmo...

1-Phenyl-3-pyrazolidinone

PYRAZOLIDONE A

1-Phenyl-3-oxopyrazolidine

Fenidon

1-phenylpyrazolidin-3-one

1-hydro-2-phenyl-pyrazol-5-one

phenitone

N-phenylpyrazolidin-3-one

1-P-3-P

1H-pyrazol-3-ol, 4,5-dihydro-1-phenyl-

1-Phenyl-3-pyrazolidone

UNII-H0U5612P6K

PHENIDONE A

1-phenyl-1H-pyrazolidin-3-one

2-Pyrazolin-3-ol, 1-phenyl-

3-Pyrazolidinone, 1-phenyl-

MFCD00003094

A PHENIDONE A

B PHENIDONE B

S PHENIDONE S

1-phenyl-pyrazolidin-3-on

EINECS 202-155-1

graphidone

Edaravone Impurity 16

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Phenidone
Price: ￥168.0/100g
Purity: 99.0%
Stocking Period: 3 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Phenidone
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Phenidone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Phenidone
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

Get all suppliers and price by the below link:

Phenidone suppliers

Price: ￥500/10 mM * 1 mL in DMSO

Reference only. check more Phenidone price

Phenidone

Use of Phenidone

Names

Phenidone Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Articles31

Synonyms