Phenidone

Modify Date: 2025-08-21 10:58:13

Phenidone structure	Common Name	Phenidone
	CAS Number	92-43-3	Molecular Weight	162.189
	Density	1.2±0.1 g/cm3	Boiling Point	304.1±25.0 °C at 760 mmHg
	Molecular Formula	C₉H₁₀N₂O	Melting Point	119-121 °C(lit.)
	MSDS	Chinese USA	Flash Point	137.7±23.2 °C
	Symbol	GHS07, GHS09	Signal Word	Warning

Use of Phenidone

Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat[1][2]. Phenidone is used as a photographic developer[3].

Name	Phenidone
Synonym	More Synonyms

Description	Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat[1][2]. Phenidone is used as a photographic developer[3].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
Target	COX LOX
In Vitro	Phenidone significantly inhibits the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE)[1].
In Vivo	Phenidone inhibits the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat[2].
References	[1]. Moon C, et al. Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. Brain Res. 2005;1035(2):206-210. [2]. Stern N, et al. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. Am J Hypertens. 1993;6(1):52-58. [3]. Petrakiev A, et al. Emission spectral analysis using photographic plates treated with a phenidone developer. Talanta. 1969;16(12):1583-1587.

Density	1.2±0.1 g/cm3
Boiling Point	304.1±25.0 °C at 760 mmHg
Melting Point	119-121 °C(lit.)
Molecular Formula	C₉H₁₀N₂O
Molecular Weight	162.189
Flash Point	137.7±23.2 °C
Exact Mass	162.079315
PSA	32.34000
LogP	0.20
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.620
InChIKey	CMCWWLVWPDLCRM-UHFFFAOYSA-N
SMILES	O=C1CCN(c2ccccc2)N1
Stability	Stable, but light sensitive. Incompatible with strong acids, strong oxidizing agents, strong bases.
Water Solubility	SOLUBLE IN HOT WATER

Phenidone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ8750000

CHEMICAL NAME :: 3-Pyrazolidinone, 1-phenyl-

CAS REGISTRY NUMBER :: 92-43-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C9-H10-N2-O

MOLECULAR WEIGHT :: 162.21

WISWESSER LINE NOTATION :: T5NMVTJ AR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 309 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(9),87,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(1),49,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 287 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(9),87,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1310 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(9),87,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 986 mg/kg/61D-I

TOXIC EFFECTS :: Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(9),87,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0749 No. of Facilities: 1437 (estimated) No. of Industries: 14 No. of Occupations: 7 No. of Employees: 6865 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0749 No. of Facilities: 4414 (estimated) No. of Industries: 34 No. of Occupations: 37 No. of Employees: 51775 (estimated) No. of Female Employees: 25903 (estimated)

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H411
Precautionary Statements	P273
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful;N:Dangerousfortheenvironment;
Risk Phrases	R22;R51/53
Safety Phrases	S61
RIDADR	UN 2811 6.1/PG 3
WGK Germany	2
RTECS	UQ8750000
Packaging Group	III
Hazard Class	6.1
HS Code	2933199090

Precursor 8
CAS#:59-88-1 Phenylhydrazine... CAS#:140-88-5 Ethyl acrylate ... CAS#:100-63-0 Phenylhydrazine CAS#:3314-35-0 3-Amino-4,5-dih...
CAS#:41682-87-5 3-hydroxy-propi... CAS#:26955-79-3 3-(2-phenylhydr... CAS#:79-06-1 Acrylamide Crystals CAS#:5883-17-0 N-Ethylacrylamide
DownStream 6
CAS#:113410-22-3 4-(2-hydroxyeth... CAS#:2655-46-1 2-acetyl-1-phen... CAS#:65684-98-2 2-phenyl-5-(3,4... CAS#:58469-32-2 5-chloro-2-phen...
CAS#:60588-53-6 N-(3-oxo-1-phen... CAS#:61447-57-2 5-(4-fluorophen...

HS Code	2933199090
Summary	2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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1-Phenyl-3-pyrazolidinone

PYRAZOLIDONE A

1-Phenyl-3-oxopyrazolidine

Fenidon

1-phenylpyrazolidin-3-one

1-hydro-2-phenyl-pyrazol-5-one

phenitone

N-phenylpyrazolidin-3-one

1-P-3-P

1H-pyrazol-3-ol, 4,5-dihydro-1-phenyl-

1-Phenyl-3-pyrazolidone

UNII-H0U5612P6K

PHENIDONE A

1-phenyl-1H-pyrazolidin-3-one

2-Pyrazolin-3-ol, 1-phenyl-

3-Pyrazolidinone, 1-phenyl-

MFCD00003094

A PHENIDONE A

B PHENIDONE B

S PHENIDONE S

1-phenyl-pyrazolidin-3-on

EINECS 202-155-1

graphidone

Edaravone Impurity 16

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China
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China
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Phenidone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Phenidone
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Phenidone suppliers

Price: ￥500/10 mM * 1 mL in DMSO

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Phenidone

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