Chaetominine

Modify Date: 2025-08-25 17:49:26

Chaetominine structure	Common Name	Chaetominine
	CAS Number	918659-56-0	Molecular Weight	402.40
	Density	1.6±0.1 g/cm3	Boiling Point	720.7±70.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₁₈N₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	389.6±35.7 °C

Use of Chaetominine

Chaetominine is an alkaloidal metabolite. Chaetominine has cytotoxicity against human leukemia K562 and colon cancer SW1116 cell lines. Chaetominine reduces MRP1-mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells[1][2].

Name	(2S,4R,5aS,9cS)-5a-Hydroxy-2-methyl-4-(4-oxo-3(4H)-quinazolinyl)-4,5,5a,9c-tetrahydro-3H-2a,9b-diazacyclopenta[jk]fluorene-1,3(2H)-dione
Synonym	More Synonyms

Description	Chaetominine is an alkaloidal metabolite. Chaetominine has cytotoxicity against human leukemia K562 and colon cancer SW1116 cell lines. Chaetominine reduces MRP1-mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> NF-κB >> Keap1-Nrf2 Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	PI3K, Akt, Nrf2[2]
References	[1]. Jiao RH, et al. Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015. Org Lett. [2]. Yao J, et al. Chaetominine reduces MRP1-mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells. Biochem Biophys Res Commun. 2016;473(4):867-873.

Density	1.6±0.1 g/cm3
Boiling Point	720.7±70.0 °C at 760 mmHg
Molecular Formula	C₂₂H₁₈N₄O₄
Molecular Weight	402.40
Flash Point	389.6±35.7 °C
Exact Mass	402.132813
PSA	95.74000
LogP	0.61
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.822
InChIKey	GEURDGODABUDHB-TYTLQBBQSA-N
SMILES	CC1C(=O)N2c3ccccc3C3(O)CC(n4cnc5ccccc5c4=O)C(=O)N1C23

Chaetominine

(2S,4R,5aS,9cS)-5a-Hydroxy-2-methyl-4-(4-oxo-3(4H)-quinazolinyl)-4,5,5a,9c-tetrahydro-3H-2a,9b-diazacyclopenta[jk]fluorene-1,3(2H)-dione

cc-559

3H-2a,9b-Diazacyclopenta[jk]fluorene-1,3(2H)-dione, 4,5,5a,9c-tetrahydro-5a-hydroxy-2-methyl-4-(4-oxo-3(4H)-quinazolinyl)-, (2S,4R,5aS,9cS)-

chaetomimine

(2S,4R,5aS,9cS)-5a-hydroxy-2-methyl-4-(4-oxoquinazolin-3(4H)-yl)-4,5,5a,9c-tetrahydro-3H-2a,9b-diazacyclopenta[jk]fluorene-1,3(2H)-dione

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (–)-Chaetominine
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Chaetominine
Price: $450.0/100mg $900.0/250mg $1800.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: CHAETOMININE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Chaetominine

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.