CLinDMA

Modify Date: 2024-01-13 22:48:20

CLinDMA Structure
CLinDMA structure
Common Name CLinDMA
CAS Number 908860-82-2 Molecular Weight 808.35
Density N/A Boiling Point N/A
Molecular Formula C54H97NO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CLinDMA


CLinDMA, a cationic lipid, can cause inflammatory response. CLinDMA can be used for the synthesis LNP201. LNP201 is a liposome assembly for systemic delivery of siRNA[1].

 Names

Name CLinDMA

 CLinDMA Biological Activity

Description CLinDMA, a cationic lipid, can cause inflammatory response. CLinDMA can be used for the synthesis LNP201. LNP201 is a liposome assembly for systemic delivery of siRNA[1].
Related Catalog
In Vitro LNP201 causes sustained silencing of the murine Ssb gene in the mouse liver after single or multiple doses through an RNAi mechanism. LNP201 causes an acute inflammatory response, inducing expression of numerous genes involved in innate immunity as well as mitogen-activated protein kinase (MAPK) phosphorylation in tissues[1].
References

[1]. Abrams MT, et al. Evaluation of efficacy, biodistribution, and inflammation for a potent siRNA nanoparticle: effect of dexamethasone co-treatment. Mol Ther. 2010;18(1):171-180.

 Chemical & Physical Properties

Molecular Formula C54H97NO3
Molecular Weight 808.35