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908860-82-2

908860-82-2 structure
908860-82-2 structure
  • Name: CLinDMA
  • Chemical Name: CLinDMA
  • CAS Number: 908860-82-2
  • Molecular Formula: C54H97NO3
  • Molecular Weight: 808.35
  • Catalog: Research Areas Inflammation/Immunology
  • Create Date: 2022-04-28 17:11:06
  • Modify Date: 2024-01-13 22:48:20
  • CLinDMA, a cationic lipid, can cause inflammatory response. CLinDMA can be used for the synthesis LNP201. LNP201 is a liposome assembly for systemic delivery of siRNA[1].

Name CLinDMA
Description CLinDMA, a cationic lipid, can cause inflammatory response. CLinDMA can be used for the synthesis LNP201. LNP201 is a liposome assembly for systemic delivery of siRNA[1].
Related Catalog
In Vitro LNP201 causes sustained silencing of the murine Ssb gene in the mouse liver after single or multiple doses through an RNAi mechanism. LNP201 causes an acute inflammatory response, inducing expression of numerous genes involved in innate immunity as well as mitogen-activated protein kinase (MAPK) phosphorylation in tissues[1].
References

[1]. Abrams MT, et al. Evaluation of efficacy, biodistribution, and inflammation for a potent siRNA nanoparticle: effect of dexamethasone co-treatment. Mol Ther. 2010;18(1):171-180.

Molecular Formula C54H97NO3
Molecular Weight 808.35