Inflachromene
Modify Date: 2024-10-06 02:06:13
Inflachromene structure
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Common Name | Inflachromene | ||
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| CAS Number | 908568-01-4 | Molecular Weight | 377.393 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 532.6±60.0 °C at 760 mmHg | |
| Molecular Formula | C21H19N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 275.9±32.9 °C | |
Use of InflachromeneInflachromene (ICM) is a microglial inhibitor with anti-inflammatory effects, directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells; blocks the sequential processes of cytoplasmic localization and extracellular release of HMGBs by perturbing its post-translational modification; effectively downregulates proinflammatory functions of HMGB and reduces neuronal damage in vivo. |
| Name | Inflachromene |
|---|---|
| Synonym | More Synonyms |
| Description | Inflachromene (ICM) is a microglial inhibitor with anti-inflammatory effects, directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells; blocks the sequential processes of cytoplasmic localization and extracellular release of HMGBs by perturbing its post-translational modification; effectively downregulates proinflammatory functions of HMGB and reduces neuronal damage in vivo. |
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| References | References 1. Lee S, et al. Nat Chem Biol. 2014 Dec;10(12):1055-60. 2. Cho W, et al. J Med Chem. 2017 Jan 12;60(1):170-179. View Related Products by Target Other Targets |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 532.6±60.0 °C at 760 mmHg |
| Molecular Formula | C21H19N3O4 |
| Molecular Weight | 377.393 |
| Flash Point | 275.9±32.9 °C |
| Exact Mass | 377.137543 |
| LogP | 1.86 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.747 |
| Inflachromene |
| 1H,7H-[1]Benzopyrano[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione, 5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl- |
| 10-Hydroxy-7,7-dimethyl-2-phenyl-5,12b-dihydro-1H,7H-chromeno[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione |