Inflachromene

Names

[ Name ]:
Inflachromene

[Synonym ]:
Inflachromene
1H,7H-[1]Benzopyrano[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione, 5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl-
10-Hydroxy-7,7-dimethyl-2-phenyl-5,12b-dihydro-1H,7H-chromeno[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione

Biological Activity

[Description]:

Inflachromene (ICM) is a microglial inhibitor with anti-inflammatory effects, directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells; blocks the sequential processes of cytoplasmic localization and extracellular release of HMGBs by perturbing its post-translational modification; effectively downregulates proinflammatory functions of HMGB and reduces neuronal damage in vivo.

[References]

References 1. Lee S, et al. Nat Chem Biol. 2014 Dec;10(12):1055-60. 2. Cho W, et al. J Med Chem. 2017 Jan 12;60(1):170-179. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
532.6±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₁₉N₃O₄

[ Molecular Weight ]:
377.393

[ Flash Point ]:
275.9±32.9 °C

[ Exact Mass ]:
377.137543

[ LogP ]:
1.86

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.747

Related Compounds

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