NSC49652
Modify Date: 2024-01-13 12:00:07
NSC49652 structure
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Common Name | NSC49652 | ||
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| CAS Number | 908563-68-8 | Molecular Weight | 225.243 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 414.3±45.0 °C at 760 mmHg | |
| Molecular Formula | C14H11NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 204.4±28.7 °C | |
Use of NSC49652NSC49652 (NSC 49652) is a compound targeting the transmembrane domain (TMD) of death receptor p75NTR with IC50 of 10 uM in AraTM assays, alters the relative conformation of p75NTR TMDs and induces dynamic changes in the full-length receptor in mammalian cells; induces apoptosis through p75NTR and the JNK pathway in neurons and affects the viability of melanoma cells, reduces tumor growth and improves survival in human melanoma xenograft model, orally available. |
| Name | (2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propen-1-one |
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| Synonym | More Synonyms |
| Description | NSC49652 (NSC 49652) is a compound targeting the transmembrane domain (TMD) of death receptor p75NTR with IC50 of 10 uM in AraTM assays, alters the relative conformation of p75NTR TMDs and induces dynamic changes in the full-length receptor in mammalian cells; induces apoptosis through p75NTR and the JNK pathway in neurons and affects the viability of melanoma cells, reduces tumor growth and improves survival in human melanoma xenograft model, orally available. |
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| References | References 1. Goh ETH, et al. Cell Chem Biol. 2018 Oct 1. pii: S2451-9456(18)30302-7. View Related Products by Target Trk Receptor |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 414.3±45.0 °C at 760 mmHg |
| Molecular Formula | C14H11NO2 |
| Molecular Weight | 225.243 |
| Flash Point | 204.4±28.7 °C |
| Exact Mass | 225.078979 |
| LogP | 2.76 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.661 |
| Storage condition | 2-8°C |
| 2-Propen-1-one, 1-(2-hydroxyphenyl)-3-(3-pyridinyl)-, (2E)- |
| (2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propen-1-one |
| MFCD00499170 |