908563-68-8

908563-68-8 structure

Name: NSC49652
Chemical Name: (2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propen-1-one
CAS Number: 908563-68-8
Molecular Formula: C₁₄H₁₁NO₂
Molecular Weight: 225.243
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2020-01-20 12:05:57
Modify Date: 2024-01-13 12:00:07
NSC49652 (NSC 49652) is a compound targeting the transmembrane domain (TMD) of death receptor p75NTR with IC50 of 10 uM in AraTM assays, alters the relative conformation of p75NTR TMDs and induces dynamic changes in the full-length receptor in mammalian cells; induces apoptosis through p75NTR and the JNK pathway in neurons and affects the viability of melanoma cells, reduces tumor growth and improves survival in human melanoma xenograft model, orally available.

Name	(2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propen-1-one
Synonyms	2-Propen-1-one, 1-(2-hydroxyphenyl)-3-(3-pyridinyl)-, (2E)- (2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propen-1-one MFCD00499170

Description	NSC49652 (NSC 49652) is a compound targeting the transmembrane domain (TMD) of death receptor p75NTR with IC50 of 10 uM in AraTM assays, alters the relative conformation of p75NTR TMDs and induces dynamic changes in the full-length receptor in mammalian cells; induces apoptosis through p75NTR and the JNK pathway in neurons and affects the viability of melanoma cells, reduces tumor growth and improves survival in human melanoma xenograft model, orally available.
References	References 1. Goh ETH, et al. Cell Chem Biol. 2018 Oct 1. pii: S2451-9456(18)30302-7. View Related Products by Target Trk Receptor