(3S,4S)-3-(5,6-Dihydro-4H-Pyrrolo[3,2,1-Ij]Quinolin-1-Yl)-4-(1H-Indol-3-Yl)Pyrrolidine-2,5-Dione

Modify Date: 2025-09-12 19:06:02

(3S,4S)-3-(5,6-Dihydro-4H-Pyrrolo[3,2,1-Ij]Quinolin-1-Yl)-4-(1H-Indol-3-Yl)Pyrrolidine-2,5-Dione structure	Common Name	(3S,4S)-3-(5,6-Dihydro-4H-Pyrrolo[3,2,1-Ij]Quinolin-1-Yl)-4-(1H-Indol-3-Yl)Pyrrolidine-2,5-Dione
	CAS Number	905854-03-7	Molecular Weight	369.41600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₁₉N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (3S,4S)-3-(5,6-Dihydro-4H-Pyrrolo[3,2,1-Ij]Quinolin-1-Yl)-4-(1H-Indol-3-Yl)Pyrrolidine-2,5-Dione

(3S,4S)-Tivantinib is a potent and highly selective inhibitor of the receptor tyrosine kinase c-MET. (3S,4S)-Tivantinib has two novel targets, GSK3α and GSK3β, which play an important role in the cellular mechanism of non-small cell lung cancer (NSCLC)[1].

Name	2,5-Pyrrolidinedione, 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-, (3S,4S)
Synonym	More Synonyms

Description	(3S,4S)-Tivantinib is a potent and highly selective inhibitor of the receptor tyrosine kinase c-MET. (3S,4S)-Tivantinib has two novel targets, GSK3α and GSK3β, which play an important role in the cellular mechanism of non-small cell lung cancer (NSCLC)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Remsing Rix LL, et al. GSK3 alpha and beta are new functionally relevant targets of tivantinib in lung cancer cells. ACS Chem Biol. 2014 Feb 21;9(2):353-8.

Molecular Formula	C₂₃H₁₉N₃O₂
Molecular Weight	369.41600
Exact Mass	369.14800
PSA	66.89000
LogP	3.92140
InChIKey	UCEQXRCJXIVODC-WOJBJXKFSA-N
SMILES	O=C1NC(=O)C(c2cn3c4c(cccc24)CCC3)C1c1c[nH]c2ccccc12
Storage condition	2-8°C

Precursor 0
DownStream 1
CAS#:905854-02-6 Tivantinib (ARQ 197)

(+-)-trans-2-Propylamino-cyclohexanol-(1)

(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4(1H-indol-3-yl)pyrrolidine-2,5-dione

2-(propylamino)cyclohexanol

(-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

(1R,2R)-2-(PROPYLAMINO)CYCLOHEXANOL

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(3S,4S)-3-(5,6-Dihydro-4H-Pyrrolo[3,2,1-Ij]Quinolin-1-Yl)-4-(1H-Indol-3-Yl)Pyrrolidine-2,5-Dione

Use of (3S,4S)-3-(5,6-Dihydro-4H-Pyrrolo[3,2,1-Ij]Quinolin-1-Yl)-4-(1H-Indol-3-Yl)Pyrrolidine-2,5-Dione

Names

Biological Activity

Chemical & Physical Properties

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.