(3S,4S)-3-(5,6-Dihydro-4H-Pyrrolo[3,2,1-Ij]Quinolin-1-Yl)-4-(1H-Indol-3-Yl)Pyrrolidine-2,5-Dione

Names

[ Name ]:
(3S,4S)-3-(5,6-Dihydro-4H-Pyrrolo[3,2,1-Ij]Quinolin-1-Yl)-4-(1H-Indol-3-Yl)Pyrrolidine-2,5-Dione

[Synonym ]:
(+-)-trans-2-Propylamino-cyclohexanol-(1)
(+)-3(S),4(S)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4(1H-indol-3-yl)pyrrolidine-2,5-dione
2-(propylamino)cyclohexanol
(-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
(1R,2R)-2-(PROPYLAMINO)CYCLOHEXANOL

Biological Activity

[Description]:

(3S,4S)-Tivantinib is a potent and highly selective inhibitor of the receptor tyrosine kinase c-MET. (3S,4S)-Tivantinib has two novel targets, GSK3α and GSK3β, which play an important role in the cellular mechanism of non-small cell lung cancer (NSCLC)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Remsing Rix LL, et al. GSK3 alpha and beta are new functionally relevant targets of tivantinib in lung cancer cells. ACS Chem Biol. 2014 Feb 21;9(2):353-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₁₉N₃O₂

[ Molecular Weight ]:
369.41600

[ Exact Mass ]:
369.14800

[ PSA ]:
66.89000

[ LogP ]:
3.92140

[ Storage condition ]:
2-8°C

Precursor & DownStream

Precursor

DownStream

Related Compounds

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