| Description |
FeTPPS, a 5,10,15,20-tetrakis (4-sulfonatophenyl) porphyrin iron III chloride peroxynitrite decomposition catalyst, possessed evident neuroprotective effects in a experimental model of spinal cord damage[1]. FeTPPS acts as a peroxynitrite scavenger and anti-nitrating agent in vivo. FeTPPS reduces nitric oxide (NO) production and apoptosis process[2].
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| Related Catalog |
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| In Vitro |
FeTPPS act as an effective pro-oxidant towards appreciable substrates in vitro in the presence of oxidant. FeTPPS protect cells against oxidative damage induced by H2O2, generated by Glucose (G)-glucose oxidase (GO) system[2]. Cell Viability Assay[2] Cell Line: Human hepatocellular carcinoma (HepG2) Concentration: 5, 10, 15, 20, 25 μM Incubation Time: Treated 12 h before being exposed to H2O2 Result: Could protect cells against oxidative damage induced by H2O2.
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| References |
[1]. Giuseppe Bruschetta, et al. FeTPPS Reduces Secondary Damage and Improves Neurobehavioral Functions after Traumatic Brain Injury.Front Neurosci. 2017 Feb 7;11:6. [2]. Pengfei Zhang, et al. Study on the detoxification mechanisms to 5,10,15,20-tetrakis (4-sulfonatophenyl) porphyrinato iron(III) chloride (FeTPPS), an efficient pro-oxidant of heme water-soluble analogue. J Inorg Biochem. 2018 Dec;189:40-52.
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