90384-82-0

90384-82-0 structure

Name: FeTPPS
Chemical Name: Chloro[4,4',4'',4'''-(5,10,15,20-porphyrintetrayl-κ2N21,N23)tetrabenzenesulfonato(2-)]iro
CAS Number: 90384-82-0
Molecular Formula: C₄₄H₂₈ClFeN₄O₁₂S₄
Molecular Weight: 1024.27
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2016-07-15 22:26:20
Modify Date: 2024-01-03 16:49:42
FeTPPS, a 5,10,15,20-tetrakis (4-sulfonatophenyl) porphyrin iron III chloride peroxynitrite decomposition catalyst, possessed evident neuroprotective effects in a experimental model of spinal cord damage[1]. FeTPPS acts as a peroxynitrite scavenger and anti-nitrating agent in vivo. FeTPPS reduces nitric oxide (NO) production and apoptosis process[2].

Name	Chloro[4,4',4'',4'''-(5,10,15,20-porphyrintetrayl-κ2N21,N23)tetrabenzenesulfonato(2-)]iro

Description	FeTPPS, a 5,10,15,20-tetrakis (4-sulfonatophenyl) porphyrin iron III chloride peroxynitrite decomposition catalyst, possessed evident neuroprotective effects in a experimental model of spinal cord damage[1]. FeTPPS acts as a peroxynitrite scavenger and anti-nitrating agent in vivo. FeTPPS reduces nitric oxide (NO) production and apoptosis process[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology
In Vitro	FeTPPS act as an effective pro-oxidant towards appreciable substrates in vitro in the presence of oxidant. FeTPPS protect cells against oxidative damage induced by H2O2, generated by Glucose (G)-glucose oxidase (GO) system[2]. Cell Viability Assay[2] Cell Line: Human hepatocellular carcinoma (HepG2) Concentration: 5, 10, 15, 20, 25 μM Incubation Time: Treated 12 h before being exposed to H2O2 Result: Could protect cells against oxidative damage induced by H2O2.
References	[1]. Giuseppe Bruschetta, et al. FeTPPS Reduces Secondary Damage and Improves Neurobehavioral Functions after Traumatic Brain Injury.Front Neurosci. 2017 Feb 7;11:6. [2]. Pengfei Zhang, et al. Study on the detoxification mechanisms to 5,10,15,20-tetrakis (4-sulfonatophenyl) porphyrinato iron(III) chloride (FeTPPS), an efficient pro-oxidant of heme water-soluble analogue. J Inorg Biochem. 2018 Dec;189:40-52.