H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt

Modify Date: 2024-01-10 16:57:07

H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt Structure
H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt structure
Common Name H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt
CAS Number 90105-47-8 Molecular Weight 388.89000
Density N/A Boiling Point N/A
Molecular Formula C17H29ClN4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt


Ala-Ala-Pro-Val-chloromethylketone is an irreversible human neutrophil elastase (NE) inhibitor for use in the study of chronic inflammatory airway diseases[1].

 Names

Name H-Ala-Ala-Pro-Val-chloromethylketone
Synonym More Synonyms

  Biological Activity

Description Ala-Ala-Pro-Val-chloromethylketone is an irreversible human neutrophil elastase (NE) inhibitor for use in the study of chronic inflammatory airway diseases[1].
Related Catalog
In Vivo Methoxysuccinyl-Ala-Ala-Pro-Val chloromethylketone (oropharyngeal aspiration; 85 μM, 40 μL; days 1, 4, and 7) blocks NE-induced cupped cell chemotaxis and significantly reduces Muc5ac gene and protein expression in male Balb/c mice[1].

 Chemical & Physical Properties

Molecular Formula C17H29ClN4O4
Molecular Weight 388.89000
Exact Mass 388.18800
PSA 121.60000
LogP 1.19800

 Synthetic Route

~%

H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt Structure

H-Ala-Ala-Pro-V...

CAS#:90105-47-8

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388

~%

H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt Structure

H-Ala-Ala-Pro-V...

CAS#:90105-47-8

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388

~%

H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt Structure

H-Ala-Ala-Pro-V...

CAS#:90105-47-8

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388

~%

H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt Structure

H-Ala-Ala-Pro-V...

CAS#:90105-47-8

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388

~%

H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt Structure

H-Ala-Ala-Pro-V...

CAS#:90105-47-8

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388

~%

H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt Structure

H-Ala-Ala-Pro-V...

CAS#:90105-47-8

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388

~%

H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt Structure

H-Ala-Ala-Pro-V...

CAS#:90105-47-8

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388

~%

H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt Structure

H-Ala-Ala-Pro-V...

CAS#:90105-47-8

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388

~%

H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt Structure

H-Ala-Ala-Pro-V...

CAS#:90105-47-8

Literature: Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388

 Synonyms

h-ala-ala-pro-val-cmk
ala-ala-pro-val-chloromethylketone
ala-ala-pro-val-cmk
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