H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt
Names
[ CAS No. ]:
90105-47-8
[ Name ]:
H-Ala-Ala-Pro-Val-chloromethylketone hydrochloride salt
[Synonym ]:
h-ala-ala-pro-val-cmk
ala-ala-pro-val-chloromethylketone
ala-ala-pro-val-cmk
Biological Activity
[Description]:
Ala-Ala-Pro-Val-chloromethylketone is an irreversible human neutrophil elastase (NE) inhibitor for use in the study of chronic inflammatory airway diseases[1].
[Related Catalog]:
[In Vivo]
Methoxysuccinyl-Ala-Ala-Pro-Val chloromethylketone (oropharyngeal aspiration; 85 μM, 40 μL; days 1, 4, and 7) blocks NE-induced cupped cell chemotaxis and significantly reduces Muc5ac gene and protein expression in male Balb/c mice[1].
Chemical & Physical Properties
[ Molecular Formula ]:
C17H29ClN4O4
[ Molecular Weight ]:
388.89000
[ Exact Mass ]:
388.18800
[ PSA ]:
121.60000
[ LogP ]:
1.19800